Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2983542..2984343 Replicon chromosome
Accession NZ_CP051725
Organism Escherichia coli strain SCU-112

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag HHJ29_RS14345 Protein ID WP_000854739.1
Coordinates 2983542..2983922 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HHJ29_RS14350 Protein ID WP_001285482.1
Coordinates 2983969..2984343 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ29_RS14310 2979133..2979687 - 555 WP_001001909.1 molecular chaperone YcdY -
HHJ29_RS14315 2979711..2980448 - 738 WP_000283664.1 zinc-binding phosphatase -
HHJ29_RS14320 2980503..2981441 - 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
HHJ29_RS14330 2981928..2982755 - 828 WP_001304477.1 DUF4942 domain-containing protein -
HHJ29_RS14335 2982840..2983037 - 198 WP_000772027.1 DUF957 domain-containing protein -
HHJ29_RS14340 2983057..2983545 - 489 WP_001054232.1 hypothetical protein -
HHJ29_RS14345 2983542..2983922 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
HHJ29_RS14350 2983969..2984343 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ29_RS14355 2984393..2985037 - 645 WP_000094915.1 hypothetical protein -
HHJ29_RS14360 2985056..2985277 - 222 WP_000692312.1 DUF987 domain-containing protein -
HHJ29_RS14365 2985340..2985816 - 477 WP_001313574.1 RadC family protein -
HHJ29_RS14370 2985832..2986305 - 474 WP_000855076.1 antirestriction protein -
HHJ29_RS14375 2986568..2987389 - 822 WP_001234710.1 DUF945 domain-containing protein -
HHJ29_RS14380 2987490..2987723 - 234 WP_000902034.1 DUF905 family protein -
HHJ29_RS14385 2987802..2988257 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T155059 WP_000854739.1 NZ_CP051725:c2983922-2983542 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T155059 NZ_CP068616:53921-54403 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT155059 WP_001285482.1 NZ_CP051725:c2984343-2983969 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT155059 NZ_CP068616:53667-53933 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References