Detailed information of TA system TA155048

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1878004..1878830
• Replicon: chromosome
• Accession: NZ_CP051725
• Organism: Escherichia coli strain SCU-112

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HHJ29_RS08765
• Protein ID: WP_001620456.1
• Coordinates: 1878004..1878378 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HHJ29_RS08770
• Protein ID: WP_024186744.1
• Coordinates: 1878468..1878830 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ29_RS08725	1873400..1874566	+	1167	WP_001297905.1	serine-type D-Ala-D-Ala carboxypeptidase DacD	-
HHJ29_RS08730	1874685..1875158	+	474	WP_001105376.1	DNA gyrase inhibitor SbmC	-
HHJ29_RS08735	1875356..1876414	+	1059	WP_001200890.1	FUSC family protein	-
HHJ29_RS08740	1876586..1876915	+	330	WP_000450409.1	DUF496 family protein	-
HHJ29_RS08745	1877016..1877198	-	183	WP_001016348.1	hypothetical protein	-
HHJ29_RS08750	1877252..1877398	+	147	Protein_1709	transposase domain-containing protein	-
HHJ29_RS08755	1877687..1877800	-	114	WP_001161660.1	DUF957 domain-containing protein	-
HHJ29_RS08760	1877813..1878007	-	195	WP_000988601.1	hypothetical protein	-
HHJ29_RS08765	1878004..1878378	-	375	WP_001620456.1	TA system toxin CbtA family protein	Toxin
HHJ29_RS08770	1878468..1878830	-	363	WP_024186744.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ29_RS08775	1878909..1879130	-	222	WP_000692312.1	DUF987 domain-containing protein	-
HHJ29_RS08780	1879199..1879675	-	477	WP_001186708.1	RadC family protein	-
HHJ29_RS08785	1879691..1880176	-	486	WP_000206667.1	antirestriction protein	-
HHJ29_RS08790	1880268..1881089	-	822	WP_001620455.1	DUF945 domain-containing protein	-
HHJ29_RS08795	1881310..1881720	-	411	WP_000846704.1	hypothetical protein	-
HHJ29_RS08800	1881736..1882413	-	678	WP_001362823.1	hypothetical protein	-
HHJ29_RS08805	1882549..1883619	-	1071	WP_000102631.1	patatin-like phospholipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (16-115)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14077.11 Da
• Isoelectric Point: 7.7761

>T155048 WP_001620456.1 NZ_CP051725:c1878378-1878004 [Escherichia coli]
MKTLPDTHIREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTQFADERVIELHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Nucleotide

• Length: 375 bp

>T155048 NZ_CP068614:325718-326086 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13354.17 Da
• Isoelectric Point: 6.6247

>AT155048 WP_024186744.1 NZ_CP051725:c1878830-1878468 [Escherichia coli]
VSDTLPGTTHPDNNRPWWGLPCTVMPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGEL
NPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKK

Nucleotide

• Length: 363 bp

>AT155048 NZ_CP068614:325500-325721 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA