155040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 37989..38632 Replicon plasmid pSCU-116-2
Accession NZ_CP051721
Organism Escherichia coli strain SCU-116

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag HHJ31_RS24805 Protein ID WP_001034046.1
Coordinates 38216..38632 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag HHJ31_RS24800 Protein ID WP_001261278.1
Coordinates 37989..38219 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ31_RS24770 33500..33805 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
HHJ31_RS24775 33807..34025 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
HHJ31_RS24780 34592..35104 + 513 WP_000151784.1 hypothetical protein -
HHJ31_RS24785 35138..36271 - 1134 WP_001542067.1 DUF3800 domain-containing protein -
HHJ31_RS24790 36438..37211 - 774 WP_000905949.1 hypothetical protein -
HHJ31_RS24795 37224..37724 - 501 WP_000528931.1 hypothetical protein -
HHJ31_RS24800 37989..38219 + 231 WP_001261278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HHJ31_RS24805 38216..38632 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
HHJ31_RS24810 38677..42471 - 3795 WP_211196987.1 pcar -
HHJ31_RS24815 42852..43082 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HHJ31_RS24820 43079..43495 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD iucA / iucB / iucC / iucD / iutA 1..65217 65217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T155040 WP_001034046.1 NZ_CP051721:38216-38632 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T155040 NZ_CP068610:1950071-1950173 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT155040 WP_001261278.1 NZ_CP051721:37989-38219 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT155040 NZ_CP068610:c1950180-1950035 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References