Detailed information of TA system TA154975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4090601..4091421
• Replicon: chromosome
• Accession: NZ_CP051714
• Organism: Escherichia coli strain SCU-122

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: HHJ35_RS19550
• Protein ID: WP_001054379.1
• Coordinates: 4090601..4090858 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HHJ35_RS19555
• Protein ID: WP_000123957.1
• Coordinates: 4090870..4091421 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ35_RS19530	4085888..4086994	+	1107	WP_001332032.1	N-acetylneuraminate epimerase	-
HHJ35_RS19535	4087058..4088038	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HHJ35_RS19540	4088621..4089847	-	1227	Protein_3816	DNA helicase	-
HHJ35_RS19545	4089925..4090224	+	300	WP_001332034.1	GNAT family N-acetyltransferase	-
HHJ35_RS19550	4090601..4090858	+	258	WP_001054379.1	YjhX family toxin	Toxin
HHJ35_RS19555	4090870..4091421	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
HHJ35_RS19560	4091473..4092219	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
HHJ35_RS19565	4092347..4092607	+	261	WP_000077645.1	hypothetical protein	-
HHJ35_RS24190	4092645..4092761	+	117	Protein_3822	VOC family protein	-
HHJ35_RS19570	4093006..4094127	+	1122	WP_000010833.1	M42 family metallopeptidase	-
HHJ35_RS19575	4094124..4094402	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HHJ35_RS19580	4094414..4095727	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4083096..4099642	16546

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T154975 WP_001054379.1 NZ_CP051714:4090601-4090858 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T154975 NZ_CP068562:3450141-3450344 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT154975 WP_000123957.1 NZ_CP051714:4090870-4091421 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT154975 NZ_CP068562:3449719-3450078 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAAGGGCATCTGGTCCACTAA

Structures

Toxin

• AlphaFold DB: B6I030