154971

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3945962..3946320 Replicon chromosome
Accession NZ_CP051714
Organism Escherichia coli strain SCU-122

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HHJ35_RS18830 Protein ID WP_001332330.1
Coordinates 3945962..3946084 (-) Length 41 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HHJ35_RS18835 Protein ID WP_000125566.1
Coordinates 3946087..3946320 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ35_RS18800 3941444..3942730 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
HHJ35_RS18805 3942730..3943719 + 990 WP_000241229.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HHJ35_RS18810 3943716..3944537 + 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HHJ35_RS18815 3944540..3944917 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HHJ35_RS18820 3944924..3945772 + 849 WP_000257201.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HHJ35_RS18825 3945769..3945921 - 153 WP_146692624.1 CcdB family protein -
HHJ35_RS18830 3945962..3946084 - 123 WP_001332330.1 CcdB family protein Toxin
HHJ35_RS18835 3946087..3946320 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HHJ35_RS18840 3946406..3946885 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
HHJ35_RS18845 3947077..3948939 - 1863 WP_000377122.1 glutathione-regulated potassium-efflux system protein KefC -
HHJ35_RS18850 3948932..3949462 - 531 WP_000600749.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HHJ35_RS18855 3949570..3950901 - 1332 WP_001183207.1 MFS transporter -
HHJ35_RS18860 3950960..3951247 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-39)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4563.34 Da        Isoelectric Point: 10.9266

>T154971 WP_001332330.1 NZ_CP051714:c3946084-3945962 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIVGEINRRIVIPLTPI

Download         Length: 123 bp

>T154971 NZ_CP068560:2989550-2989702 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT154971 WP_000125566.1 NZ_CP051714:c3946320-3946087 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT154971 NZ_CP068560:c2989746-2989646 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References