Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3515118..3515736 Replicon chromosome
Accession NZ_CP051714
Organism Escherichia coli strain SCU-122

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ35_RS16835 Protein ID WP_001291435.1
Coordinates 3515518..3515736 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ35_RS16830 Protein ID WP_000344800.1
Coordinates 3515118..3515492 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ35_RS16820 3510208..3511401 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HHJ35_RS16825 3511424..3514573 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HHJ35_RS16830 3515118..3515492 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ35_RS16835 3515518..3515736 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ35_RS16840 3515910..3516461 + 552 WP_000102543.1 maltose O-acetyltransferase -
HHJ35_RS16845 3516577..3517047 + 471 WP_000136192.1 YlaC family protein -
HHJ35_RS16850 3517211..3518761 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ35_RS16855 3518803..3519156 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ35_RS16865 3519535..3519846 + 312 WP_000409908.1 MGMT family protein -
HHJ35_RS16870 3519877..3520449 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T154969 WP_001291435.1 NZ_CP051714:3515518-3515736 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154969 NZ_CP068557:2399649-2399801 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT154969 WP_000344800.1 NZ_CP051714:3515118-3515492 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT154969 NZ_CP068557:c2399845-2399745 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References