Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4175866..4176484 Replicon chromosome
Accession NZ_CP051711
Organism Escherichia coli strain SCU-123

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ36_RS19915 Protein ID WP_001291435.1
Coordinates 4175866..4176084 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ36_RS19920 Protein ID WP_000344800.1
Coordinates 4176110..4176484 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ36_RS19880 4171153..4171725 + 573 WP_000779831.1 YbaY family lipoprotein -
HHJ36_RS19885 4171756..4172067 - 312 WP_000409908.1 MGMT family protein -
HHJ36_RS19895 4172446..4172799 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ36_RS19900 4172841..4174391 - 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ36_RS19905 4174555..4175025 - 471 WP_000136192.1 YlaC family protein -
HHJ36_RS19910 4175141..4175692 - 552 WP_000102543.1 maltose O-acetyltransferase -
HHJ36_RS19915 4175866..4176084 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ36_RS19920 4176110..4176484 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ36_RS19925 4177029..4180178 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HHJ36_RS19930 4180201..4181394 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T154946 WP_001291435.1 NZ_CP051711:c4176084-4175866 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154946 NZ_CP068443:330020-330364 [Pantoea agglomerans]
ATGGACGCACTATTCATCGAACTTTCCAGCTTCCAGAAATACCGGGCTGATTATCTGAATGATGATCAGTACAGGCTGTT
TCAGAACATGTTGCTGGCTGACCCTGAGAAGGGCGATGTGATACCCGATACCGGCGGACTGCGTAAAGTTCGCTTCAGGG
ATGAGCGCCGACACAAGGGCGCACGTGGCGGGATCAGGGTTATCTATTACTGGACCAACACACAAGGCCAATTCATCCTG
TTTACCATCTACGATAAAGATCAACGCGACGATTTGACCAGGCAACAGCGTGATGCCCTGGCGACCGCGCTGAATGTGAT
CAAAAAAGGACTGAGACATGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT154946 WP_000344800.1 NZ_CP051711:c4176484-4176110 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT154946 NZ_CP068443:330357-330671 [Pantoea agglomerans]
ATGACTGAACGCGATATCTTCAGTGAACTGATGACGGGTATGCAGGAGCTTAAGGATCATCAGGAGGGCAAAATTACGCT
TAAGAGTTATAAGGTCACTAAGCGTGCCCCTGTAACTATTGCGCCGCAGGAGTTACGCGACGTACGCGAAAAACTGAACC
TCTCACAGGCCGTATTCGCCCATTATCTTCATACTGGCGAAACGACATATCAAAACTGGGAACAGGGCAGGGCGAGACCT
AACGCCCAGGCTGTTTTACTGATCCGCATGGTGCAGCAGAACCCAGAAACGCTGAAGACGCTCGCGAAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References