Detailed information of TA system TA154940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3601758..3602578
• Replicon: chromosome
• Accession: NZ_CP051711
• Organism: Escherichia coli strain SCU-123

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: HHJ36_RS17210
• Protein ID: WP_001054379.1
• Coordinates: 3602321..3602578 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HHJ36_RS17205
• Protein ID: WP_000123957.1
• Coordinates: 3601758..3602309 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ36_RS17180	3597452..3598765	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
HHJ36_RS17185	3598777..3599055	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HHJ36_RS17190	3599052..3600173	-	1122	WP_000010833.1	M42 family metallopeptidase	-
HHJ36_RS25690	3600418..3600534	-	117	Protein_3351	VOC family protein	-
HHJ36_RS17195	3600572..3600832	-	261	WP_000077645.1	hypothetical protein	-
HHJ36_RS17200	3600960..3601706	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
HHJ36_RS17205	3601758..3602309	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
HHJ36_RS17210	3602321..3602578	-	258	WP_001054379.1	YjhX family toxin	Toxin
HHJ36_RS17215	3602955..3603254	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
HHJ36_RS17220	3603332..3604558	+	1227	Protein_3357	helicase YjhR	-
HHJ36_RS17225	3605141..3606121	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HHJ36_RS17230	3606185..3607291	-	1107	WP_001332032.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T154940 WP_001054379.1 NZ_CP051711:c3602578-3602321 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T154940 NZ_CP068440:c980163-979948 [Pantoea agglomerans]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGCTGCCGCTCTCTTGATACCCTGGAAAGGGTGAT
TGAAAAAAATAAGTATGAATTACCGGAAGATGAATTAGCGGTATTTTACTCAGCGGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTCTACGATAAAGTCCCGGGTTCAGTATGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT154940 WP_000123957.1 NZ_CP051711:c3602309-3601758 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT154940 NZ_CP068440:c980565-980188 [Pantoea agglomerans]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTTTGTGAGAGCCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCATGGCTGGGTTAATGATCCCACTTCTGAAAGCAATCTACAGCTTAACGATTTGATTGAGC
ATATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTATTCAGCAATTATGGTGTCAATAGTCCGGATCTTCAGCGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCGAGCCATTCATTATAG

Structures

Toxin

• AlphaFold DB: B6I030