Detailed information of TA system TA154939

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3568741..3569575
• Replicon: chromosome
• Accession: NZ_CP051711
• Organism: Escherichia coli strain SCU-123

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1J6XFW9
• Locus tag: HHJ36_RS17050
• Protein ID: WP_000854770.1
• Coordinates: 3569198..3569575 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HHJ36_RS17045
• Protein ID: WP_001332042.1
• Coordinates: 3568741..3569109 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ36_RS17020	3565865..3566023	+	159	WP_001323397.1	DUF905 family protein	-
HHJ36_RS17025	3566178..3566996	+	819	WP_001234738.1	DUF945 domain-containing protein	-
HHJ36_RS17030	3567338..3567802	+	465	WP_000855061.1	antirestriction protein	-
HHJ36_RS17035	3567818..3568294	+	477	WP_001557203.1	RadC family protein	-
HHJ36_RS17040	3568357..3568578	+	222	WP_000692323.1	DUF987 domain-containing protein	-
HHJ36_RS17045	3568741..3569109	+	369	WP_001332042.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ36_RS17050	3569198..3569575	+	378	WP_000854770.1	TA system toxin CbtA family protein	Toxin
HHJ36_RS17055	3569572..3570060	+	489	WP_000761690.1	hypothetical protein	-
HHJ36_RS17060	3570077..3570253	+	177	WP_000839286.1	DUF957 domain-containing protein	-
HHJ36_RS25685	3570353..3570511	+	159	WP_001467148.1	hypothetical protein	-
HHJ36_RS17075	3570875..3571051	+	177	Protein_3327	helix-turn-helix domain-containing protein	-
HHJ36_RS17080	3571533..3573070	+	1538	WP_085953974.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14196.37 Da
• Isoelectric Point: 8.7438

>T154939 WP_000854770.1 NZ_CP051711:3569198-3569575 [Escherichia coli]
MKTLPDTHVRKVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Nucleotide

• Length: 378 bp

>T154939 NZ_CP068440:718434-718613 [Pantoea agglomerans]
ATGGATAGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAAGGATAAACGGTAGCCATCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGGTCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13677.38 Da
• Isoelectric Point: 6.5931

>AT154939 WP_001332042.1 NZ_CP051711:3568741-3569109 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAFYPTSETKK

Nucleotide

• Length: 369 bp

>AT154939 NZ_CP068440:718640-719065 [Pantoea agglomerans]
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCACGAACACGCATACGGGGTAATCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGCAGATACTCTTGATGAAGCCATCAAAAACGCCAAAGAGGCTATCACGGGGCATATCGAATTATGTGTAGAGC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGGCTCTGGCCACGAATCCTGACTATCAGGGTTATATCTGGGCATTG
GTTGATGTTGATGTCATTCGCTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGCTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCGGAATACAAAAGTCGCTCGGGCTTTCTGGCTCAGATAGCGCTTGAGCGTATTACTG
CTCCGATTAACAGGCCTCAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A1J6XFW9