Detailed information of TA system TA154938

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3312270..3313104
• Replicon: chromosome
• Accession: NZ_CP051711
• Organism: Escherichia coli strain SCU-123

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B7MK10
• Locus tag: HHJ36_RS15755
• Protein ID: WP_000854820.1
• Coordinates: 3312270..3312647 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: HHJ36_RS15760
• Protein ID: WP_001285610.1
• Coordinates: 3312736..3313104 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ36_RS15735	3308834..3310372	-	1539	WP_001187191.1	lysine decarboxylation/transport transcriptional activator CadC	-
HHJ36_RS15740	3311206..3311766	-	561	Protein_3067	DUF4942 domain-containing protein	-
HHJ36_RS15745	3311851..3312048	-	198	WP_085949158.1	DUF957 domain-containing protein	-
HHJ36_RS15750	3312076..3312273	-	198	Protein_3069	hypothetical protein	-
HHJ36_RS15755	3312270..3312647	-	378	WP_000854820.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HHJ36_RS15760	3312736..3313104	-	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ36_RS15765	3313184..3313405	-	222	WP_000692347.1	DUF987 domain-containing protein	-
HHJ36_RS15770	3313492..3313968	-	477	WP_001186193.1	RadC family protein	-
HHJ36_RS15775	3313983..3314462	-	480	WP_000706978.1	antirestriction protein	-
HHJ36_RS15780	3314728..3315546	-	819	WP_001175155.1	DUF945 domain-containing protein	-
HHJ36_RS15785	3315636..3315869	-	234	WP_001278287.1	DUF905 family protein	-
HHJ36_RS15790	3315875..3316552	-	678	WP_016235129.1	hypothetical protein	-
HHJ36_RS15795	3316703..3317383	-	681	WP_001278649.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	papX	3301345..3374167	72822

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14043.12 Da
• Isoelectric Point: 7.8839

>T154938 WP_000854820.1 NZ_CP051711:c3312647-3312270 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Nucleotide

• Length: 378 bp

>T154938 NZ_CP068440:294983-295336 [Pantoea agglomerans]
ATGTGGGATGTGGATACAACCAAAAGATTTGATGAATGGTTTAAGGCTCAGACTGAGGAACTGAAGGAGGATATGCTCGC
CGCGATAGTTATCCTGTCTGAGTATGGGCCGCATTTAGCGAGGCCGTTTGCTGATACTGTAGACGGCTCTGATTTTCCGA
ATATGAAAGAATTAAGAGTGCAGCATCAAGGCAAACCGATACGGGCCTTCTTTGCTTTTGATCCTTCTCGCCGCGGCATT
GTGTTGTGTGCAGGCGATAAAACCGGGGTTAAGGAAAAGAAATTCTATAAAGACATGATCAAATTGGCAGATGCTGAATT
CCGCAAATATTTGAATGGAGGGGATAATGGCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT154938 WP_001285610.1 NZ_CP051711:c3313104-3312736 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT154938 NZ_CP068440:295329-295628 [Pantoea agglomerans]
ATGGCTAATTTAAAAGAGCTGATGGCAAATCAAAGTCCGGAGAGTCGCGAACGCATTGCCAAAAAAGTCGATGCAATGCG
GCAGGTTATCGCGCTACACATGTTGCGCGAAGAACTTAATCTGTCACAGACAGAGATGGCGCATGCAATGGGTGTGAAAC
AGCCAACTATCGCCAGAATGGAACAGGCTGATAATGATCCCCGCCTTTCTACGCTGAAGCGTTACGTTACGGCTCTGGGA
GGCGAGATAAGTATCGATGTCAAATTGCCGACAGGCAAAAGAATAGCTTTTGATCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0E2KXX6