Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1947335..1948136 | Replicon | chromosome |
| Accession | NZ_CP051711 | ||
| Organism | Escherichia coli strain SCU-123 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D8EBK0 |
| Locus tag | HHJ36_RS09315 | Protein ID | WP_001094436.1 |
| Coordinates | 1947759..1948136 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7MN76 |
| Locus tag | HHJ36_RS09310 | Protein ID | WP_015953067.1 |
| Coordinates | 1947335..1947712 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHJ36_RS09275 | 1943247..1943927 | + | 681 | WP_021527957.1 | WYL domain-containing protein | - |
| HHJ36_RS09280 | 1944075..1944752 | + | 678 | WP_001097312.1 | hypothetical protein | - |
| HHJ36_RS09285 | 1944758..1944991 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
| HHJ36_RS09290 | 1945081..1945899 | + | 819 | WP_001175142.1 | DUF945 domain-containing protein | - |
| HHJ36_RS09295 | 1945990..1946475 | + | 486 | WP_001596890.1 | antirestriction protein | - |
| HHJ36_RS09300 | 1946490..1946966 | + | 477 | WP_001186756.1 | RadC family protein | - |
| HHJ36_RS09305 | 1947035..1947256 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| HHJ36_RS09310 | 1947335..1947712 | + | 378 | WP_015953067.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| HHJ36_RS09315 | 1947759..1948136 | + | 378 | WP_001094436.1 | TA system toxin CbtA family protein | Toxin |
| HHJ36_RS09320 | 1948133..1948621 | + | 489 | WP_000761714.1 | hypothetical protein | - |
| HHJ36_RS09325 | 1948633..1948830 | + | 198 | WP_000839254.1 | DUF957 domain-containing protein | - |
| HHJ36_RS09330 | 1948915..1949760 | + | 846 | WP_001280513.1 | DUF4942 domain-containing protein | - |
| HHJ36_RS09335 | 1949831..1951366 | + | 1536 | WP_000492897.1 | EAL domain-containing protein | - |
| HHJ36_RS09340 | 1951763..1951933 | + | 171 | Protein_1828 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | papG / papF / papE / papK / papJ / papD / papC / papH / papA / papB / papI / kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / neuE / neuC / neuA / neuB / neuD / kpsT / kpsM / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC / rfaE | 1899188..2088988 | 189800 | |
| - | flank | IS/Tn | - | - | 1951829..1951933 | 104 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13958.84 Da Isoelectric Point: 6.8603
>T154935 WP_001094436.1 NZ_CP051711:1947759-1948136 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ
Download Length: 378 bp
>T154935 NZ_CP068436:c105254-104874 [Cupriavidus necator]
ATGAGCGTACTCGTCGACACCTCTGTATGGGTCAATCATTTTAAGAACCGCAATGACGCACTGGTCAATTTGGTCGTGTC
GGATCAAGCGCTGACCCACCCTATCGTCCTGGTTGAATTGGCTTGCGGGACACCCCCTGCACCACGTGTCCGGACACTCG
GCGACATTGGACTGTTGCAGCCGGCAAAGCAGGCCAGCCTAGCAGAGGTAATGGCATTCATCGAGCACGAGAAATTGTAT
GGGCTGGGCTGCGGCCTGGTGGACGTCTCACTGCTGGCTTCCACTTTGATCACACCGGGCGCACAGCTATGGACACTGGA
CAAGCGTCTCGACGATTTATCAGTGCGTTTTGGTGTGGCGCATCGACCCAAACTTCACTAG
ATGAGCGTACTCGTCGACACCTCTGTATGGGTCAATCATTTTAAGAACCGCAATGACGCACTGGTCAATTTGGTCGTGTC
GGATCAAGCGCTGACCCACCCTATCGTCCTGGTTGAATTGGCTTGCGGGACACCCCCTGCACCACGTGTCCGGACACTCG
GCGACATTGGACTGTTGCAGCCGGCAAAGCAGGCCAGCCTAGCAGAGGTAATGGCATTCATCGAGCACGAGAAATTGTAT
GGGCTGGGCTGCGGCCTGGTGGACGTCTCACTGCTGGCTTCCACTTTGATCACACCGGGCGCACAGCTATGGACACTGGA
CAAGCGTCTCGACGATTTATCAGTGCGTTTTGGTGTGGCGCATCGACCCAAACTTCACTAG
Antitoxin
Download Length: 126 a.a. Molecular weight: 13766.60 Da Isoelectric Point: 6.2021
>AT154935 WP_015953067.1 NZ_CP051711:1947335-1947712 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT154935 NZ_CP068436:c105457-105251 [Cupriavidus necator]
ATGCGCACCACCGTCACCATCGATGACGCCCTCTATGAACAAGCGCTAGAGGTGGCCGACCCTAACATGGACAAATCCGA
CCTTTTTCGTGAGGCGATTAAAACTTTCGTTCGGGTGCAAGCGGCCAAGCGCCTCGCGGCATTGGGTGGGGCCGCCCCAG
ACATGCAAGATGTGCCACGTCGTCGCACGGAGCCTGAAGCGAAATGA
ATGCGCACCACCGTCACCATCGATGACGCCCTCTATGAACAAGCGCTAGAGGTGGCCGACCCTAACATGGACAAATCCGA
CCTTTTTCGTGAGGCGATTAAAACTTTCGTTCGGGTGCAAGCGGCCAAGCGCCTCGCGGCATTGGGTGGGGCCGCCCCAG
ACATGCAAGATGTGCCACGTCGTCGCACGGAGCCTGAAGCGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2L1N0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z3CIS0 |