Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1829404..1830058 Replicon chromosome
Accession NZ_CP051711
Organism Escherichia coli strain SCU-123

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HHJ36_RS08700 Protein ID WP_000244781.1
Coordinates 1829404..1829811 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HHJ36_RS08705 Protein ID WP_000354046.1
Coordinates 1829792..1830058 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ36_RS08680 1825361..1827094 - 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -
HHJ36_RS08685 1827100..1827810 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HHJ36_RS08690 1827835..1828731 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
HHJ36_RS08695 1828843..1829364 + 522 WP_001055874.1 flavodoxin FldB -
HHJ36_RS08700 1829404..1829811 - 408 WP_000244781.1 protein YgfX Toxin
HHJ36_RS08705 1829792..1830058 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HHJ36_RS08710 1830301..1831281 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
HHJ36_RS08715 1831358..1832017 - 660 WP_000250274.1 hemolysin III family protein -
HHJ36_RS08720 1832181..1832492 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
HHJ36_RS08725 1832537..1833970 + 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T154934 WP_000244781.1 NZ_CP051711:c1829811-1829404 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T154934 NZ_CP068435:1588864-1589142 [Cupriavidus necator]
ATGATCCAGTCATTCAGATGTTCCGACACCGCTGAACTGTTCGCGGGCCGCTGTGTACCACGCTTCGGCAATATCCGCAC
CGTGGCCGAACGCAAGCTGCGGCTGCTGCAGAGAGCGTCGACGCTAGAGTTCCTGCGTTCGCCGCCGGGCAATCGCCTGC
AGTTGCTGACGGGCGACCGCAAAGGCCGCTACAGCATCCGCATCAACGAACAGTGGCGAATCTGCTTCATCTGGACCCAC
GACGGCCCCGCGGCCGTTGAGATCATCGACAATCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT154934 WP_000354046.1 NZ_CP051711:c1830058-1829792 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT154934 NZ_CP068435:1589154-1589489 [Cupriavidus necator]
GTGGTTCGCTTCAAGGACGGCATGCGTCCCATCCACCCGGGCGAAATCCTGCGCGAGGATTTCCTGGTACCGCTCAACAT
GAGCGCCAACGCCCTGGCCCTTGCGCTGCGCGTGACCGCGGCGCGCATCAACGACATCGTCCGCGAGCAACGTGGCATCA
CGCCGGACACCGCCCTGCGCCTGGCGCGCTATTTTGGCGGCGATGCGCAGTCGTGGCTGAACCTGCAGCTGGACTATGAC
CTGAAGGTCGCGCAGCGCGACCATGGCGAGCGGATCATGGCGGAAGTGGCGCCACGCAATGCGGCGGCGGCCGGTCAGCC
GGCTGCGGAAAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References