Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3400991..3401609 Replicon chromosome
Accession NZ_CP051706
Organism Escherichia coli strain SCU-124

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ37_RS16490 Protein ID WP_001291435.1
Coordinates 3401391..3401609 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ37_RS16485 Protein ID WP_000344800.1
Coordinates 3400991..3401365 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ37_RS16475 3396081..3397274 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HHJ37_RS16480 3397297..3400446 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HHJ37_RS16485 3400991..3401365 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ37_RS16490 3401391..3401609 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ37_RS16495 3401782..3402333 + 552 WP_001524178.1 maltose O-acetyltransferase -
HHJ37_RS16500 3402449..3402919 + 471 WP_000136192.1 YlaC family protein -
HHJ37_RS16505 3403083..3404633 + 1551 WP_001524176.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ37_RS16510 3404675..3405028 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ37_RS16520 3405407..3405718 + 312 WP_000409908.1 MGMT family protein -
HHJ37_RS16525 3405749..3406321 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T154909 WP_001291435.1 NZ_CP051706:3401391-3401609 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154909 NZ_CP068394:c1906241-1906139 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT154909 WP_000344800.1 NZ_CP051706:3400991-3401365 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT154909 NZ_CP068394:1906101-1906369 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References