Detailed information of TA system TA154906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2383001..2384589
• Replicon: chromosome
• Accession: NZ_CP051706
• Organism: Escherichia coli strain SCU-124

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HHJ37_RS11505
• Protein ID: WP_001524713.1
• Coordinates: 2383267..2384589 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A061YNW4
• Locus tag: HHJ37_RS11500
• Protein ID: WP_001296076.1
• Coordinates: 2383001..2383267 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ37_RS11485	2379369..2380820	+	1452	WP_000854638.1	tagaturonate reductase	-
HHJ37_RS11490	2381017..2381931	+	915	WP_001385356.1	bestrophin family protein	-
HHJ37_RS11495	2381935..2382693	-	759	WP_001524715.1	trans-aconitate 2-methyltransferase	-
HHJ37_RS11500	2383001..2383267	+	267	WP_001296076.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HHJ37_RS11505	2383267..2384589	+	1323	WP_001524713.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HHJ37_RS11510	2385501..2386064	+	564	WP_001296074.1	type 1 fimbrial major subunit FimA	-
HHJ37_RS11515	2386428..2387138	+	711	WP_001195177.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49341.97 Da
• Isoelectric Point: 7.7906

>T154906 WP_001524713.1 NZ_CP051706:2383267-2384589 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLVPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Nucleotide

• Length: 1323 bp

>T154906 NZ_CP068394:c1308445-1308338 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9987.34 Da
• Isoelectric Point: 4.9632

>AT154906 WP_001296076.1 NZ_CP051706:2383001-2383267 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT154906 NZ_CP068394:1308501-1308562 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A061YNW4