Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2741868..2742703 Replicon chromosome
Accession NZ_CP051700
Organism Escherichia coli strain SCU-125

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VR61
Locus tag HHJ38_RS13680 Protein ID WP_000854747.1
Coordinates 2742326..2742703 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3P1Z1K5
Locus tag HHJ38_RS13675 Protein ID WP_021538665.1
Coordinates 2741868..2742236 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ38_RS13640 2737602..2738486 + 885 WP_000010387.1 50S ribosome-binding GTPase -
HHJ38_RS13645 2738605..2739282 + 678 WP_001097364.1 hypothetical protein -
HHJ38_RS13650 2739288..2739521 + 234 WP_021538212.1 DUF905 family protein -
HHJ38_RS13655 2739622..2740440 + 819 WP_001234693.1 DUF945 domain-containing protein -
HHJ38_RS13660 2740532..2741017 + 486 WP_021538211.1 antirestriction protein -
HHJ38_RS13665 2741033..2741509 + 477 WP_158302277.1 RadC family protein -
HHJ38_RS13670 2741572..2741793 + 222 WP_000692345.1 DUF987 domain-containing protein -
HHJ38_RS13675 2741868..2742236 + 369 WP_021538665.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ38_RS13680 2742326..2742703 + 378 WP_000854747.1 TA system toxin CbtA family protein Toxin
HHJ38_RS13685 2742700..2743188 + 489 WP_000761667.1 hypothetical protein -
HHJ38_RS13690 2743200..2743397 + 198 WP_000839291.1 DUF957 domain-containing protein -
HHJ38_RS13695 2743482..2744336 + 855 WP_001588930.1 DUF4942 domain-containing protein -
HHJ38_RS13700 2745073..2746611 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14095.03 Da        Isoelectric Point: 6.8524

>T154886 WP_000854747.1 NZ_CP051700:2742326-2742703 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T154886 NZ_CP068386:4061034-4061561 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGCCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13465.18 Da        Isoelectric Point: 6.2015

>AT154886 WP_021538665.1 NZ_CP051700:2741868-2742236 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNQLHYLADHAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK

Download         Length: 369 bp

>AT154886 NZ_CP068386:4060747-4061037 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VFZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A3P1Z1K5

References