Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2625562..2626396 Replicon chromosome
Accession NZ_CP051700
Organism Escherichia coli strain SCU-125

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag HHJ38_RS13030 Protein ID WP_000854689.1
Coordinates 2626019..2626396 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag HHJ38_RS13025 Protein ID WP_001285599.1
Coordinates 2625562..2625942 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ38_RS12990 2621573..2622028 + 456 WP_000581506.1 hypothetical protein -
HHJ38_RS12995 2622129..2622337 + 209 Protein_2536 DUF905 family protein -
HHJ38_RS13000 2622438..2623259 + 822 WP_016244184.1 DUF945 domain-containing protein -
HHJ38_RS26010 2623259..2623506 + 248 Protein_2538 antirestriction protein -
HHJ38_RS13005 2623600..2624073 + 474 WP_000855059.1 antirestriction protein -
HHJ38_RS13010 2624089..2624565 + 477 WP_158302277.1 RadC family protein -
HHJ38_RS13015 2624628..2624849 + 222 WP_000692345.1 DUF987 domain-containing protein -
HHJ38_RS13020 2624868..2625512 + 645 WP_000086755.1 hypothetical protein -
HHJ38_RS13025 2625562..2625942 + 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ38_RS13030 2626019..2626396 + 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
HHJ38_RS13035 2626393..2626881 + 489 WP_001530850.1 hypothetical protein -
HHJ38_RS13040 2626893..2627090 + 198 WP_000839236.1 DUF957 domain-containing protein -
HHJ38_RS13045 2627204..2628022 + 819 WP_001545729.1 DUF4942 domain-containing protein -
HHJ38_RS13050 2628294..2628944 - 651 WP_000056749.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
HHJ38_RS13055 2628958..2629422 - 465 WP_000776505.1 PTS ascorbate transporter subunit IIA -
HHJ38_RS13060 2629432..2629737 - 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
HHJ38_RS13065 2629753..2631150 - 1398 WP_000404886.1 PTS ascorbate transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T154885 WP_000854689.1 NZ_CP051700:2626019-2626396 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T154885 NZ_CP068386:2404648-2404751 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT154885 WP_001285599.1 NZ_CP051700:2625562-2625942 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT154885 NZ_CP068386:c2404753-2404608 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References