Detailed information of TA system TA154884

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2395668..2396500
• Replicon: chromosome
• Accession: NZ_CP051700
• Organism: Escherichia coli strain SCU-125

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HHJ38_RS11955
• Protein ID: WP_000854754.1
• Coordinates: 2395668..2396042 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HHJ38_RS11960
• Protein ID: WP_169063556.1
• Coordinates: 2396132..2396500 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ38_RS11915	2390883..2391989	+	1107	WP_001315214.1	N-acetylneuraminate epimerase	-
HHJ38_RS11920	2392054..2393034	+	981	WP_001295601.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
HHJ38_RS11925	2393042..2393692	-	651	WP_169063555.1	HNH endonuclease	-
HHJ38_RS11940	2394737..2394889	-	153	WP_001280445.1	hypothetical protein	-
HHJ38_RS11945	2394974..2395171	-	198	WP_000839281.1	DUF957 domain-containing protein	-
HHJ38_RS11950	2395183..2395671	-	489	WP_100273043.1	hypothetical protein	-
HHJ38_RS11955	2395668..2396042	-	375	WP_000854754.1	TA system toxin CbtA family protein	Toxin
HHJ38_RS11960	2396132..2396500	-	369	WP_169063556.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HHJ38_RS11965	2396663..2396884	-	222	WP_000692345.1	DUF987 domain-containing protein	-
HHJ38_RS11970	2396947..2397423	-	477	WP_158302277.1	RadC family protein	-
HHJ38_RS11975	2397439..2397924	-	486	WP_000849588.1	antirestriction protein	-
HHJ38_RS11980	2397979..2398797	-	819	WP_023156757.1	DUF945 domain-containing protein	-
HHJ38_RS11985	2398898..2399107	-	210	Protein_2336	DUF905 family protein	-
HHJ38_RS11990	2399208..2399663	-	456	WP_000581506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14019.97 Da
• Isoelectric Point: 8.2905

>T154884 WP_000854754.1 NZ_CP051700:c2396042-2395668 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEKR

Nucleotide

• Length: 375 bp

>T154884 NZ_CP068386:c1670125-1669907 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13461.19 Da
• Isoelectric Point: 5.4488

>AT154884 WP_169063556.1 NZ_CP051700:c2396500-2396132 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT154884 NZ_CP068386:c1670527-1670153 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAAGGCCAATCCTGTTAGTTTGTCTTGTTAA