Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1818557..1819175 Replicon chromosome
Accession NZ_CP051700
Organism Escherichia coli strain SCU-125

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ38_RS09215 Protein ID WP_001291435.1
Coordinates 1818957..1819175 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ38_RS09210 Protein ID WP_000344800.1
Coordinates 1818557..1818931 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ38_RS09200 1813647..1814840 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HHJ38_RS09205 1814863..1818012 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HHJ38_RS09210 1818557..1818931 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ38_RS09215 1818957..1819175 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ38_RS09220 1819348..1819899 + 552 WP_000102539.1 maltose O-acetyltransferase -
HHJ38_RS09225 1820015..1820485 + 471 WP_000136192.1 YlaC family protein -
HHJ38_RS09230 1820649..1822199 + 1551 WP_021523794.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ38_RS09235 1822241..1822594 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ38_RS09245 1822973..1823284 + 312 WP_000409908.1 MGMT family protein -
HHJ38_RS09250 1823315..1823887 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T154880 WP_001291435.1 NZ_CP051700:1818957-1819175 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154880 NZ_CP051700:1818957-1819175 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT154880 WP_000344800.1 NZ_CP051700:1818557-1818931 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT154880 NZ_CP051700:1818557-1818931 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References