Detailed information of TA system TA154877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 753398..754986
• Replicon: chromosome
• Accession: NZ_CP051700
• Organism: Escherichia coli strain SCU-125

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8E0MJW1
• Locus tag: HHJ38_RS03925
• Protein ID: WP_021524177.1
• Coordinates: 753664..754986 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HHJ38_RS03920
• Protein ID: WP_001332145.1
• Coordinates: 753398..753664 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ38_RS03905	749766..751217	+	1452	WP_000854636.1	tagaturonate reductase	-
HHJ38_RS03910	751414..752328	+	915	WP_001306069.1	bestrophin family protein	-
HHJ38_RS03915	752332..753090	-	759	WP_001286588.1	trans-aconitate 2-methyltransferase	-
HHJ38_RS03920	753398..753664	+	267	WP_001332145.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HHJ38_RS03925	753664..754986	+	1323	WP_021524177.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HHJ38_RS03930	755379..756116	-	738	WP_024188296.1	LysR family transcriptional regulator	-
HHJ38_RS03935	756117..756554	+	438	Protein_768	NAD(P)H-binding protein	-
HHJ38_RS03940	757330..757893	+	564	WP_001327671.1	type 1 fimbrial major subunit FimA	-
HHJ38_RS03945	758255..758965	+	711	WP_001195181.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49384.16 Da
• Isoelectric Point: 8.9380

>T154877 WP_021524177.1 NZ_CP051700:753664-754986 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRGRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Nucleotide

• Length: 1323 bp

>T154877 NZ_CP068386:c548524-548213 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10016.44 Da
• Isoelectric Point: 6.2267

>AT154877 WP_001332145.1 NZ_CP051700:753398-753664 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT154877 NZ_CP068386:c548216-547770 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAATCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG