Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4164979..4165574 Replicon chromosome
Accession NZ_CP051698
Organism Escherichia coli strain SCU-152

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HHJ40_RS19830 Protein ID WP_000239579.1
Coordinates 4164979..4165329 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HHJ40_RS19835 Protein ID WP_001223208.1
Coordinates 4165323..4165574 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ40_RS19810 4160425..4161447 - 1023 WP_001296689.1 ABC transporter permease -
HHJ40_RS19815 4161461..4162963 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
HHJ40_RS19820 4163103..4164059 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HHJ40_RS19825 4164369..4164899 + 531 WP_000055072.1 inorganic diphosphatase -
HHJ40_RS19830 4164979..4165329 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HHJ40_RS19835 4165323..4165574 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HHJ40_RS19840 4165787..4166128 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HHJ40_RS19845 4166131..4169910 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T154861 WP_000239579.1 NZ_CP051698:c4165329-4164979 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T154861 NZ_CP068286:c1428136-1427828 [Ralstonia syzygii subsp. celebesensis]
ATGCTGACAATCCGCACGACTGAAATCTTCGACGACTGGTTTTACAGTCTCCGCGACAAGGCCGCGCAACGCCGCGTCCA
GGTGCGCATCGATCGCCTGCAGATGGGCAATCCAGGCGATGTGAAAACCGTACGTGAAGGCATCCGTGAGATGCGGATCG
ATCATGGCCCGGGCTATCGCGTGTATGTTGCGCAGCGTGGCGTGGTCCTGATCGTCCTGCTGTGCGGCGGTGACAAGTCG
ACGCAGGAAGCCGATGTCCGCCGCGCAATCGACCTGTCCCGCCGTCTTGACGTGGACAACATGGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT154861 WP_001223208.1 NZ_CP051698:c4165574-4165323 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT154861 NZ_CP068286:c1427831-1427526 [Ralstonia syzygii subsp. celebesensis]
ATGATGATGGCCCAACGCACCATAAAGACCCGGCCGTGGGATTCGGCCGAACACCTCCGGACCGAAGCGGACATCGCCGC
CTATCTCGACGCCTGCCTGGAGGAAGCCGGGGATGACCCCGCATTCATCACGCACGCGCTGGGCGTGGTCGCGCGGGCGC
GCGGCATGACGCAGATCGCCCGCGAGACCGGGATGACGCGCGAAGGGCTGTACAAGGCGCTTTCCGAGGACGGCAATCCG
AGCTTTGCGACCGTGCTGAAGGTCATCCGGGCGCTCGGCATCCGGCTGCACGCCGTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References