Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49341..50179 Replicon chromosome
Accession NZ_CP051698
Organism Escherichia coli strain SCU-152

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HHJ40_RS00250 Protein ID WP_169059468.1
Coordinates 49341..49721 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HHJ40_RS00255 Protein ID WP_169059469.1
Coordinates 49811..50179 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ40_RS00220 44698..45621 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
HHJ40_RS00225 45732..46916 - 1185 WP_001172875.1 sugar efflux transporter -
HHJ40_RS00235 47711..48554 - 844 Protein_45 DUF4942 domain-containing protein -
HHJ40_RS00240 48639..48836 - 198 WP_021581277.1 DUF957 domain-containing protein -
HHJ40_RS00245 48856..49344 - 489 WP_169059467.1 hypothetical protein -
HHJ40_RS00250 49341..49721 - 381 WP_169059468.1 TA system toxin CbtA family protein Toxin
HHJ40_RS00255 49811..50179 - 369 WP_169059469.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ40_RS00260 50330..50551 - 222 WP_169059470.1 DUF987 domain-containing protein -
HHJ40_RS00265 50620..51096 - 477 WP_137594896.1 RadC family protein -
HHJ40_RS00270 51112..51588 - 477 WP_169059471.1 antirestriction protein -
HHJ40_RS00275 51670..52491 - 822 WP_169059472.1 DUF945 domain-containing protein -
HHJ40_RS00280 52592..52777 - 186 WP_169059623.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14129.05 Da        Isoelectric Point: 6.4763

>T154839 WP_169059468.1 NZ_CP051698:c49721-49341 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
RAGAPSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 381 bp

>T154839 NZ_CP068283:c2157433-2157182 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13756.63 Da        Isoelectric Point: 7.0268

>AT154839 WP_169059469.1 NZ_CP051698:c50179-49811 [Escherichia coli]
VSDKLPGITHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLQMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT154839 NZ_CP068283:c2157185-2156931 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References