Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
Location | 5213..5772 | Replicon | plasmid pSCU-313-1 |
Accession | NZ_CP051695 | ||
Organism | Escherichia coli strain SCU-313 |
Toxin (Protein)
Gene name | relE | Uniprot ID | V0SVC8 |
Locus tag | HHJ46_RS24420 | Protein ID | WP_000421272.1 |
Coordinates | 5213..5488 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | V0SRR3 |
Locus tag | HHJ46_RS24425 | Protein ID | WP_001387467.1 |
Coordinates | 5488..5772 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HHJ46_RS24390 | 1263..2003 | - | 741 | WP_001066942.1 | tyrosine-type recombinase/integrase | - |
HHJ46_RS24395 | 2124..2306 | - | 183 | WP_042065278.1 | hypothetical protein | - |
HHJ46_RS24400 | 2649..2956 | - | 308 | Protein_3 | type II toxin-antitoxin system ParD family antitoxin | - |
HHJ46_RS24405 | 3449..4618 | + | 1170 | WP_001072355.1 | hypothetical protein | - |
HHJ46_RS24410 | 4651..4779 | + | 129 | Protein_5 | IS481 family transposase | - |
HHJ46_RS24415 | 4814..5107 | - | 294 | WP_001105060.1 | hypothetical protein | - |
HHJ46_RS24420 | 5213..5488 | - | 276 | WP_000421272.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HHJ46_RS24425 | 5488..5772 | - | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
HHJ46_RS24430 | 6377..7129 | + | 753 | WP_000562172.1 | IclR family transcriptional regulator | - |
HHJ46_RS24435 | 7175..8140 | - | 966 | WP_001022265.1 | 2-keto-3-deoxygluconate transporter | - |
HHJ46_RS24440 | 8173..8553 | - | 381 | WP_000710783.1 | Rid family detoxifying hydrolase | - |
HHJ46_RS24445 | 8578..9468 | - | 891 | WP_001077068.1 | dihydrodipicolinate synthase family protein | - |
HHJ46_RS24450 | 9701..9895 | - | 195 | WP_000796505.1 | hypothetical protein | - |
HHJ46_RS24455 | 9869..10309 | + | 441 | Protein_14 | zinc-binding dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aadA5 / qacE / sul1 / mph(A) / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / aac(3)-IId / blaTEM-1B / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..105394 | 105394 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10749.45 Da Isoelectric Point: 10.0871
>T154830 WP_000421272.1 NZ_CP051695:c5488-5213 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T154830 NZ_CP068283:c1304626-1304519 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT154830 WP_001387467.1 NZ_CP051695:c5772-5488 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
Download Length: 285 bp
>AT154830 NZ_CP068283:1304673-1304739 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0SVC8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0Y880 |