Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2679245..2679883 Replicon chromosome
Accession NZ_CP051694
Organism Escherichia coli strain SCU-313

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag HHJ46_RS12870 Protein ID WP_000813797.1
Coordinates 2679707..2679883 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HHJ46_RS12865 Protein ID WP_076611057.1
Coordinates 2679245..2679661 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ46_RS12845 2674397..2675338 - 942 WP_001251335.1 ABC transporter permease -
HHJ46_RS12850 2675339..2676352 - 1014 WP_000220413.1 ABC transporter ATP-binding protein -
HHJ46_RS12855 2676370..2677515 - 1146 WP_000047447.1 ABC transporter substrate-binding protein -
HHJ46_RS12860 2677760..2679166 - 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
HHJ46_RS12865 2679245..2679661 - 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HHJ46_RS12870 2679707..2679883 - 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HHJ46_RS12875 2680105..2680335 + 231 WP_000494244.1 YncJ family protein -
HHJ46_RS12880 2680427..2682388 - 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HHJ46_RS12885 2682461..2682997 - 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
HHJ46_RS12890 2683050..2684261 + 1212 WP_001323162.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T154817 WP_000813797.1 NZ_CP051694:c2679883-2679707 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T154817 NZ_CP068281:c4149716-4149381 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT154817 WP_076611057.1 NZ_CP051694:c2679661-2679245 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT154817 NZ_CP068281:c4149964-4149716 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References