Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1235631..1236249 Replicon chromosome
Accession NZ_CP051688
Organism Escherichia coli strain SCU-387

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HHJ48_RS05835 Protein ID WP_001291435.1
Coordinates 1235631..1235849 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HHJ48_RS05840 Protein ID WP_000344800.1
Coordinates 1235875..1236249 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ48_RS05800 1230919..1231491 + 573 WP_000779831.1 YbaY family lipoprotein -
HHJ48_RS05805 1231522..1231833 - 312 WP_000409908.1 MGMT family protein -
HHJ48_RS05815 1232212..1232565 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HHJ48_RS05820 1232607..1234157 - 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HHJ48_RS05825 1234321..1234791 - 471 WP_000136192.1 YlaC family protein -
HHJ48_RS05830 1234907..1235458 - 552 WP_000102539.1 maltose O-acetyltransferase -
HHJ48_RS05835 1235631..1235849 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HHJ48_RS05840 1235875..1236249 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HHJ48_RS05845 1236795..1239944 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
HHJ48_RS05850 1239967..1241160 - 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T154763 WP_001291435.1 NZ_CP051688:c1235849-1235631 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154763 NZ_CP068278:232930-233238 [Corynebacterium aquatimens]
ATGACGCTCGGTGAGATATGGCAGGGAATCGCGTATCTCAAACCTGGTCGAAGACGCACCGCTCTCGAACAGAGCTTTAC
CACCTGGTTGGAGCTCATGCCGCCAGAACACGTTCTCCCCTTTGGCGCCGAGGAAGCCCGGATCTTTGGCGACGTGCGTG
CCCATCGAAAGGCAATTGGGCGACCCATAAGCTACCCAGATGCCATCATCGCAGCAACATGCATTGCTCATGATGCAACA
CTGTTCACGCGCAATACCAGCGATTTCGACGAACTCAATCTCCGCCTGGTCAACCCTTGGGAAGACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT154763 WP_000344800.1 NZ_CP051688:c1236249-1235875 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT154763 NZ_CP068278:232581-232814 [Corynebacterium aquatimens]
ATGGCTTCACTCATTGTGCGTAACTTGGATGAACGGGTAAAAGAAGCTCTGGCGGAGCGCGCCCGACTACAGGGGCGATC
CATGGAAGCCGAGGTGCGGGACATCCTGCACCGCGCCGTGGCGCCTACCAATCCCCTCGAAGAACTGCATCAGCTGGTCT
CCCGAGCTGATGCCAGCGTTGATTTGGAGCTTCCCGATCGAGTCATTGATGAGCGGGAAGTTGACTTCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References