154754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 603110..603924 Replicon chromosome
Accession NZ_CP051688
Organism Escherichia coli strain SCU-387

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag HHJ48_RS02860 Protein ID WP_001054376.1
Coordinates 603667..603924 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag HHJ48_RS02855 Protein ID WP_001540600.1
Coordinates 603110..603655 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ48_RS02830 598801..600114 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
HHJ48_RS02835 600126..600404 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
HHJ48_RS02840 600401..601522 - 1122 WP_000010829.1 M42 family metallopeptidase -
HHJ48_RS26805 601767..601883 - 117 Protein_551 VOC family protein -
HHJ48_RS02845 601921..602139 - 219 Protein_552 hypothetical protein -
HHJ48_RS02850 602308..603054 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
HHJ48_RS02855 603110..603655 - 546 WP_001540600.1 N-acetyltransferase Antitoxin
HHJ48_RS02860 603667..603924 - 258 WP_001054376.1 hypothetical protein Toxin
HHJ48_RS02865 604301..604546 - 246 Protein_556 GNAT family N-acetyltransferase -
HHJ48_RS02870 604662..605902 + 1241 Protein_557 helicase YjhR -
HHJ48_RS02875 606485..607465 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HHJ48_RS02880 607530..608636 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T154754 WP_001054376.1 NZ_CP051688:c603924-603667 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T154754 NZ_CP068249:c2637192-2636884 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGCTCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT154754 WP_001540600.1 NZ_CP051688:c603655-603110 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT154754 NZ_CP068249:c2637466-2637194 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References