Detailed information of TA system TA154751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3945730..3947427
• Replicon: chromosome
• Accession: NZ_CP051685
• Organism: Duganella sp. GN2-R2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HH212_RS17000
• Protein ID: WP_170203536.1
• Coordinates: 3945730..3947070 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HH212_RS17005
• Protein ID: WP_170203537.1
• Coordinates: 3947071..3947427 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH212_RS16990	3941138..3944212	-	3075	WP_170203534.1	hypothetical protein	-
HH212_RS16995	3944200..3945249	-	1050	WP_170203535.1	hypothetical protein	-
HH212_RS17000	3945730..3947070	-	1341	WP_170203536.1	type II toxin-antitoxin system HipA family toxin	Toxin
HH212_RS17005	3947071..3947427	-	357	WP_170203537.1	helix-turn-helix domain-containing protein	Antitoxin
HH212_RS17010	3947877..3948647	+	771	WP_170203538.1	hypothetical protein	-
HH212_RS17015	3949080..3949685	-	606	WP_170203539.1	hypothetical protein	-
HH212_RS17020	3949682..3949918	-	237	WP_170203540.1	hypothetical protein	-
HH212_RS17025	3949860..3950093	-	234	WP_170203541.1	hypothetical protein	-
HH212_RS17030	3950551..3951120	+	570	WP_170203542.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3938235..3951120	12885

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (157-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49473.17 Da
• Isoelectric Point: 6.5719

>T154751 WP_170203536.1 NZ_CP051685:c3947070-3945730 [Duganella sp. GN2-R2]
MGRRAHTQRLVLWLNGTPAAYWDASSRQNVLGYYDDWLNDEQGRPLSLSLPFRPDNAPYRGQLVENYFDNLLPDSEAIRR
RLATHFRCEGIAPYQLLTAVGRDCVGAIQLLPEGEEPADLFTIRGEPMSESQVASLLRNTTSGRLPGQADDDTDLRLSIA
GAQEKSALLWHAEQWHKPVGSTPTTHILKMPMGLVGAMQADMRTSVENEWLCSRLIRELGVPTANCDIARFEDMKVLVVE
RFDRRLSRDGTWIVRLPQEDFCQATGTSPLHKYQADGGPGISTIMEILLGSEQAAIDRINFFKTQLLFWLLAATDGHAKN
FSLFLLPGSRFQSTPAYDVLSAHPVIGTGANSLAPQKAKLAMAVRGTQNHYNLGSIQRRHWLSHARLSGLGSQAAEQIIA
DVLGRVDGAIDSVGKQLPDNFPTDLANTIFQGMLAQCDRLRRMEAT

Nucleotide

• Length: 1341 bp

>T154751 NZ_CP068247:c1881324-1881217 [Staphylococcus sp. T93]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12770.93 Da
• Isoelectric Point: 10.6575

>AT154751 WP_170203537.1 NZ_CP051685:c3947427-3947071 [Duganella sp. GN2-R2]
MTYPLKTLQQLRPILVGFRKDAGLSQAAVAALLGITQQSYAKIEVNPSTTSVERLFTILRLLGAEIILDRHAVPTSAGQS
NGIGLQDTVSPSPPVPVEKPASAKPRKMLPPNMKKENW

Nucleotide

• Length: 357 bp

>AT154751 NZ_CP068247:1881140-1881200 [Staphylococcus sp. T93]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA