Detailed information of TA system TA154750

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2536510..2537093
• Replicon: chromosome
• Accession: NZ_CP051685
• Organism: Duganella sp. GN2-R2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HH212_RS10945
• Protein ID: WP_170202503.1
• Coordinates: 2536510..2536893 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HH212_RS10950
• Protein ID: WP_170202504.1
• Coordinates: 2536890..2537093 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH212_RS10935	2534809..2535963	+	1155	WP_170202501.1	HAMP domain-containing histidine kinase	-
HH212_RS10940	2535995..2536414	+	420	WP_170202502.1	VOC family protein	-
HH212_RS10945	2536510..2536893	-	384	WP_170202503.1	VapC toxin family PIN domain ribonuclease	Toxin
HH212_RS10950	2536890..2537093	-	204	WP_170202504.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HH212_RS10955	2537729..2537923	-	195	WP_170202505.1	hypothetical protein	-
HH212_RS10960	2538152..2538949	-	798	WP_211172485.1	HNH endonuclease	-
HH212_RS10965	2538961..2540904	-	1944	WP_170202507.1	chromosome partitioning protein ParA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2536510..2577706	41196

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14074.33 Da
• Isoelectric Point: 7.1357

>T154750 WP_170202503.1 NZ_CP051685:c2536893-2536510 [Duganella sp. GN2-R2]
MKGVLVDTSVWVDHFRNRNENLVSLLTLDLALSHPLIVTELACSTPPAPRSRTLTDISTLPQARQATLDEVRGLIEREKL
YGLGCGVVDLALLASTLLTPGSRLWSLDRRLAELAQRFDVVFRPALQ

Nucleotide

• Length: 384 bp

>T154750 NZ_CP068247:c1856054-1855788 [Staphylococcus sp. T93]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7424.47 Da
• Isoelectric Point: 5.0166

>AT154750 WP_170202504.1 NZ_CP051685:c2537093-2536890 [Duganella sp. GN2-R2]
MRTTVTIDDALYEKALEMADPDMDKADLFREAIKTFVRVQAARRLASLGGASPNMANVPRRSSEPVE

Nucleotide

• Length: 204 bp

>AT154750 NZ_CP068247:c1856305-1856054 [Staphylococcus sp. T93]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA