Detailed information of TA system TA154749

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-Xre
• Location: 882314..883134
• Replicon: chromosome
• Accession: NZ_CP051685
• Organism: Duganella sp. GN2-R2

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: HH212_RS03765
• Protein ID: WP_169434155.1
• Coordinates: 882667..883134 (+)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: HH212_RS03760
• Protein ID: WP_170205250.1
• Coordinates: 882314..882670 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH212_RS03735	877492..878415	+	924	WP_169434150.1	transcriptional activator NhaR	-
HH212_RS03740	878522..879865	+	1344	WP_169434151.1	hemolysin family protein	-
HH212_RS03745	880015..880638	+	624	WP_169434152.1	glutathione S-transferase family protein	-
HH212_RS03750	880660..881487	+	828	WP_169434153.1	helix-turn-helix domain-containing protein	-
HH212_RS03755	881553..881918	+	366	WP_169434154.1	VOC family protein	-
HH212_RS03760	882314..882670	+	357	WP_170205250.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
HH212_RS03765	882667..883134	+	468	WP_169434155.1	RES family NAD+ phosphorylase	Toxin
HH212_RS03770	883405..884271	+	867	WP_169434156.1	ABC transporter ATP-binding protein	-
HH212_RS03775	884268..885830	+	1563	WP_169434157.1	hypothetical protein	-
HH212_RS03780	885898..886788	+	891	WP_169434158.1	SPFH domain-containing protein	-
HH212_RS03785	886801..886998	+	198	WP_169434159.1	hypothetical protein	-
HH212_RS03790	887172..887660	+	489	WP_169434160.1	nuclear transport factor 2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-149)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (70-115)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17247.70 Da
• Isoelectric Point: 8.8557

>T154749 WP_169434155.1 NZ_CP051685:882667-883134 [Duganella sp. GN2-R2]
MKLWRIATDTPDYTSDDMTGTGAKISGGRWNRPGTAMLYCGTNISLAVLETFVHLKAGGLPLNRYLVEINVHDDVWNKAV
DMRNPPVGWDAIPAGTVSLNTGDNWIRANTSALMVVPSVIVSEEYNVLINPLHSDTKTFQVRKVRKWTYDSRLGK

Nucleotide

• Length: 468 bp

>T154749 NZ_CP068247:c1590925-1590821 [Staphylococcus sp. T93]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13175.25 Da
• Isoelectric Point: 4.6952

>AT154749 WP_170205250.1 NZ_CP051685:882314-882670 [Duganella sp. GN2-R2]
MKAFAADLGIPQDRFFRMFGIAQATVTRKALKQQAMSVDESAKIVGMAKLVGQVETMLEQSGDPELMRDFDAPKWLARWI
EEPSPALGDKRPAEYMDTIEGQEMVSRLLSMMQTGAYA

Nucleotide

• Length: 357 bp

>AT154749 NZ_CP068247:1590727-1590765 [Staphylococcus sp. T93]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC