Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3954810..3955471 Replicon chromosome
Accession NZ_CP051684
Organism Duganella sp. AF9R3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HH213_RS18045 Protein ID WP_169113142.1
Coordinates 3955295..3955471 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HH213_RS18040 Protein ID WP_169113141.1
Coordinates 3954810..3955226 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH213_RS18005 3949923..3950381 + 459 WP_169113134.1 hypothetical protein -
HH213_RS18010 3950442..3950837 + 396 WP_169113135.1 hypothetical protein -
HH213_RS18015 3950834..3951358 + 525 WP_169113136.1 glucosaminidase domain-containing protein -
HH213_RS18020 3951420..3952127 + 708 WP_169113137.1 hypothetical protein -
HH213_RS18025 3952124..3952549 + 426 WP_169113138.1 DUF1353 domain-containing protein -
HH213_RS18030 3952569..3952958 - 390 WP_169113139.1 hypothetical protein -
HH213_RS18035 3953146..3953934 + 789 WP_174864460.1 DNA adenine methylase -
HH213_RS18040 3954810..3955226 - 417 WP_169113141.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HH213_RS18045 3955295..3955471 - 177 WP_169113142.1 type II toxin-antitoxin system HicA family toxin Toxin
HH213_RS18050 3955658..3956062 + 405 WP_169113143.1 hypothetical protein -
HH213_RS18055 3956150..3956884 + 735 WP_169113144.1 hypothetical protein -
HH213_RS18060 3957390..3957965 - 576 WP_169113145.1 SocA family protein -
HH213_RS18070 3958429..3959256 - 828 WP_169113146.1 glutamate racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6687.80 Da        Isoelectric Point: 10.9086

>T154748 WP_169113142.1 NZ_CP051684:c3955471-3955295 [Duganella sp. AF9R3]
VKQSEFVRWLRQQGATFEDGTNHLKVYLNGQKTILPRHPAKELKTGTVEGIKKQLKLK

Download         Length: 177 bp

>T154748 NZ_CP068247:c1533617-1533408 [Staphylococcus sp. T93]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14924.03 Da        Isoelectric Point: 4.3905

>AT154748 WP_169113141.1 NZ_CP051684:c3955226-3954810 [Duganella sp. AF9R3]
MKYPAHFEPAEEGGFVITFRDIPEAITQAEDEAEAAAEAASALISAMDFYFEDRRAVPPPSPALQGERLISLPASAACKI
LLLNEMVAQKVGPSELARRMGTSPQVVNRLVDLHHPTKIDTVEEALESLGKQLELVAA

Download         Length: 417 bp

>AT154748 NZ_CP068247:c1533922-1533629 [Staphylococcus sp. T93]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References