Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3175846..3176441 Replicon chromosome
Accession NZ_CP051672
Organism Parabacteroides distasonis strain CBBP-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A7L5EKT4
Locus tag HHO38_RS13970 Protein ID WP_008773898.1
Coordinates 3175846..3176088 (+) Length 81 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E1YXL0
Locus tag HHO38_RS13975 Protein ID WP_005866743.1
Coordinates 3176100..3176441 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHO38_RS13955 3171520..3172926 - 1407 WP_005866749.1 c-type cytochrome -
HHO38_RS13960 3172944..3174155 - 1212 WP_008780678.1 peptidase M75 -
HHO38_RS13965 3174186..3175499 - 1314 WP_008773897.1 hypothetical protein -
HHO38_RS13970 3175846..3176088 + 243 WP_008773898.1 type II toxin-antitoxin system HicA family toxin Toxin
HHO38_RS13975 3176100..3176441 + 342 WP_005866743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HHO38_RS13980 3176773..3177426 - 654 WP_087343578.1 transcriptional regulator -
HHO38_RS13985 3177442..3177711 - 270 WP_022192540.1 hypothetical protein -
HHO38_RS13995 3178703..3178930 + 228 WP_121962008.1 helix-turn-helix transcriptional regulator -
HHO38_RS14000 3179009..3180031 + 1023 WP_122379797.1 virulence RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(14-73)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9340.80 Da        Isoelectric Point: 9.4084

>T154742 WP_008773898.1 NZ_CP051672:3175846-3176088 [Parabacteroides distasonis]
MIERFCKLPKDFTYEETLKLLSSYGYNEHNKGATSGSCVRFKNEQTGQYIDIHKPHPGSIMKEWMMKAIYQHLKSNGLIK

Download         Length: 243 bp

>T154742 NZ_CP068244:184636-184902 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12391.06 Da        Isoelectric Point: 4.8780

>AT154742 WP_005866743.1 NZ_CP051672:3176100-3176441 [Parabacteroides distasonis]
MDYLEYKGYKGSVEYSKADNCLCGKVLGMSKDLILYEGNTIDELRADFEAGVESYLAGCLADGVEPRKPYSGTLNIRISP
EIHSRIAALAQEAGTTINGYIKQALENQLKLAH

Download         Length: 342 bp

>AT154742 NZ_CP068244:184373-184636 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L5EKT4

Antitoxin

Source ID Structure
AlphaFold DB A0A069SEG1

References