Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2205808..2206436 Replicon chromosome
Accession NZ_CP051666
Organism Marinobacterium sp. LSUCC0821

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HH196_RS10750 Protein ID WP_169452114.1
Coordinates 2206038..2206436 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HH196_RS10745 Protein ID WP_169452113.1
Coordinates 2205808..2206038 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH196_RS10705 2201096..2201362 + 267 WP_169452105.1 ribbon-helix-helix protein, CopG family -
HH196_RS10710 2201365..2201643 + 279 WP_169452106.1 type II toxin-antitoxin system RelE/ParE family toxin -
HH196_RS10715 2202084..2203238 + 1155 WP_169452107.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
HH196_RS10720 2203238..2203714 + 477 WP_169452108.1 cyclic pyranopterin monophosphate synthase MoaC -
HH196_RS10725 2203720..2203974 + 255 WP_169452109.1 molybdopterin converting factor subunit 1 -
HH196_RS10730 2203985..2204701 + 717 WP_169452110.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
HH196_RS10735 2205003..2205251 + 249 WP_169452111.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HH196_RS10740 2205241..2205525 + 285 WP_169452112.1 type II toxin-antitoxin system RelE/ParE family toxin -
HH196_RS10745 2205808..2206038 + 231 WP_169452113.1 antitoxin Antitoxin
HH196_RS10750 2206038..2206436 + 399 WP_169452114.1 tRNA(fMet)-specific endonuclease VapC Toxin
HH196_RS10755 2206760..2207239 + 480 WP_169452115.1 transcription/translation regulatory transformer protein RfaH -
HH196_RS10760 2207232..2208179 - 948 WP_169452116.1 tyrosine-type recombinase/integrase -
HH196_RS10765 2208324..2208752 + 429 WP_169452117.1 helix-turn-helix domain-containing protein -
HH196_RS10770 2208749..2209480 + 732 WP_169452118.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HH196_RS10775 2209528..2209608 + 81 WP_169452391.1 hypothetical protein -
HH196_RS10780 2209845..2210177 + 333 WP_169452119.1 MarR family EPS-associated transcriptional regulator -
HH196_RS10785 2210181..2210714 + 534 WP_211160791.1 HI0074 family nucleotidyltransferase substrate-binding subunit -
HH196_RS10790 2210704..2211003 + 300 WP_169452120.1 nucleotidyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmd 2205808..2242471 36663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14991.34 Da        Isoelectric Point: 8.0369

>T154741 WP_169452114.1 NZ_CP051666:2206038-2206436 [Marinobacterium sp. LSUCC0821]
MLKYMLDTNIVIYTIKNKPEVVRSRFKQHYGQMCISSVSYMELIFGAERSGNPEKNLRVLEGFVARMDVIPFDSEAAVHS
GQLRTELANKGTPIGPYDLMIAGHARSEGFILVTNNEKEFVRVPGLRVENWL

Download         Length: 399 bp

>T154741 NZ_CP068241:924901-925263 [Staphylococcus sp. 11-B-312]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTGTCACCAGTACAGGGTTCTGAACAAGGGGGAATAAGGCCCGTAGT
CATTATACAAAATGATACTGGTAACAAGTATAGTCCTACCGTAATTGTAGCTGCAATTACAGGTAGGATTAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGCAAGTATAAACTCGACAAAGATTCTGTTATATTGTTAGAGCAAATACGG
ACGTTAGACAAGAACAGATTAAAAGAAAAACTGACATATCTATCTGAAGAAAAAATGCAAGAAGTTAATAATGCTATAGA
TATTAGCCTAGGTTTACATAATATTAGAAATCATAGAACATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8498.52 Da        Isoelectric Point: 4.3867

>AT154741 WP_169452113.1 NZ_CP051666:2205808-2206038 [Marinobacterium sp. LSUCC0821]
MQSARIFKSNTSQAVRFPKQVALPDSVKEVDIIAMGRARLVVPSGEGWDSWFDGEAVTEDFMEVRDQPEGQARESL

Download         Length: 231 bp

>AT154741 NZ_CP068241:924734-924904 [Staphylococcus sp. 11-B-312]
ATGGCAAGTTTTAATCAAAGCAGAAATCATAGTATTGAACAACTATTAAAAGAAGGCTATTCGCAAATGGCTGACTTGAA
TCTCTCCCTTGCGGCGGAAGCATTTCCATTTGAATGTGAAGCTTGCGATTGCAATGAAGTCTACATTATATCTAAGAATA
ACAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References