Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 4502799..4503417 | Replicon | chromosome |
| Accession | NZ_CP051663 | ||
| Organism | Escherichia coli strain 1162invT2 | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | H5UYE2 |
| Locus tag | HH200_RS21955 | Protein ID | WP_001291435.1 |
| Coordinates | 4502799..4503017 (-) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | S1PTH5 |
| Locus tag | HH200_RS21960 | Protein ID | WP_000344800.1 |
| Coordinates | 4503043..4503417 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HH200_RS21920 (4498086) | 4498086..4498658 | + | 573 | WP_000779831.1 | YbaY family lipoprotein | - |
| HH200_RS21925 (4498689) | 4498689..4499000 | - | 312 | WP_000409908.1 | MGMT family protein | - |
| HH200_RS21935 (4499379) | 4499379..4499732 | + | 354 | WP_000878135.1 | DUF1428 family protein | - |
| HH200_RS21940 (4499774) | 4499774..4501324 | - | 1551 | WP_001385227.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
| HH200_RS21945 (4501488) | 4501488..4501958 | - | 471 | WP_000136192.1 | YlaC family protein | - |
| HH200_RS21950 (4502074) | 4502074..4502625 | - | 552 | WP_000102539.1 | maltose O-acetyltransferase | - |
| HH200_RS21955 (4502799) | 4502799..4503017 | - | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
| HH200_RS21960 (4503043) | 4503043..4503417 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
| HH200_RS21965 (4503963) | 4503963..4507112 | - | 3150 | WP_001132478.1 | efflux RND transporter permease AcrB | - |
| HH200_RS21970 (4507135) | 4507135..4508328 | - | 1194 | WP_001295833.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T154731 WP_001291435.1 NZ_CP051663:c4503017-4502799 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T154731 NZ_CP068238:c4350595-4349840 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTCACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA
GTGAGCGAGATCTGGCGCCTCTGCGCAGGCGAGAAGCAGGTCCGGCCGCTGCAAGGGCGGCTGGTGCGGCTGGTGGAGAG
CCAGGAGCAGGTGGCGACTCTGCAACTGGTGGATACCCTCGAGGAGCAGGCGTTGCTCGAGGAGTTGCTGGAGTCCAGCA
AGCCGCCGCTGCCGGAAAGTGCCGAGCCGCTGCATTACCTGTTGAAGACGCCGTTCCGCTATCCGCCCTTGCGCTGGGGC
TCGCGCTTCGGTCGCCGGCATGAGCCAGGCCTGTTCTATGCCGCGCTGAAACTGGAGACAGCGATGGCCGAGGGCGCCTA
TTACCGTTGCGTCCTGTGGAGCGGCATGGCGGTGCCGCCGCCCAGTGGGCGGATCCTTTCCGAGCACGCCTCGTTCGAGG
CGGCCTGGAAGGTGGAGCGGGGCGTTCGCCTGCAGGAACCGCCTTTCTCCGACTACGAGCGCGCGCTGACCGATACCGCC
GACTACCGAGTCGCCCAGGAGCTGGGTAGTGCCATGCGCGGCGCCGGTGTACAGGCATTCGAGTATCGTTCGGCGCGTTG
CCCGCAGCGTGGCTGCAATGTCGCCCTGTTCACGCCGCGGGCCTTCATCGAGAAACGTCCGCGCAACCTGACCCCATGGC
TGTGCGAAACCACCGCCAGCTATGTGGCGTTCAAGCCTGCGCACGTGCCGGGCTCGCCGAAGGTGTTCGCTCGCGAACTG
TTCCTGGTGGACGGCCGCCTGCCCCAGCCGGCATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT154731 WP_000344800.1 NZ_CP051663:c4503417-4503043 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT154731 NZ_CP068238:c4351100-4350732 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA
ATGAGCGCTCTCATCAAGGAACGCCCCAGTGCCGATGCCGTCCTGGCCAAGGCGGTGCTGGCCGCGCGCGAGCAGCTGGG
CCTGACGCAACTCGAACTGGCCGGGATCCTCGGCGTCGACCGCAGCGCCATCAGCCGCTGGAAGAGCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAACTGGCCCTGCTGCTCGTGCGGGTCTACCGCGCGCTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACCTGCGTCATTTCATGCGCACGCCCAACCATCACCTGGGCGGGGAGCCCCTGGCGCTGATGGGACAGGTACAGGG
CCTGGTGCATGTACTGGAGTACCTCGACGCGATCCGCGGCAAGGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 2MW2 | |
| PDB | 1JW2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QBQ5 |