Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3758719..3759314 Replicon chromosome
Accession NZ_CP051663
Organism Escherichia coli strain 1162invT2

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HH200_RS18355 Protein ID WP_000239579.1
Coordinates 3758964..3759314 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HH200_RS18350 Protein ID WP_001223208.1
Coordinates 3758719..3758970 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH200_RS18340 (3754384) 3754384..3758163 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
HH200_RS18345 (3758166) 3758166..3758507 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HH200_RS18350 (3758719) 3758719..3758970 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HH200_RS18355 (3758964) 3758964..3759314 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HH200_RS18360 (3759394) 3759394..3759924 - 531 WP_000055075.1 inorganic diphosphatase -
HH200_RS18365 (3760234) 3760234..3761190 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HH200_RS18370 (3761330) 3761330..3762832 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
HH200_RS18375 (3762846) 3762846..3763868 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T154724 WP_000239579.1 NZ_CP051663:3758964-3759314 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T154724 NZ_CP068237:c3988403-3988086 [Klebsiella quasipneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAGGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCACTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT154724 WP_001223208.1 NZ_CP051663:3758719-3758970 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT154724 NZ_CP068237:c3988093-3987806 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAGCACCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGAATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTCGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCATCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References