Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2841738..2842538 Replicon chromosome
Accession NZ_CP051663
Organism Escherichia coli strain 1162invT2

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag HH200_RS14095 Protein ID WP_000342452.1
Coordinates 2841738..2842265 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag HH200_RS14100 Protein ID WP_001277107.1
Coordinates 2842272..2842538 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH200_RS14070 (2836814) 2836814..2837581 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HH200_RS14075 (2837578) 2837578..2838855 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
HH200_RS14080 (2838852) 2838852..2839778 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HH200_RS14085 (2839826) 2839826..2840935 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
HH200_RS14090 (2841358) 2841358..2841741 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
HH200_RS14095 (2841738) 2841738..2842265 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
HH200_RS14100 (2842272) 2842272..2842538 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
HH200_RS14105 (2842687) 2842687..2843790 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
HH200_RS14110 (2844061) 2844061..2844915 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
HH200_RS14115 (2845160) 2845160..2846218 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
HH200_RS14120 (2846211) 2846211..2846879 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T154721 WP_000342452.1 NZ_CP051663:c2842265-2841738 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

>T154721 NZ_CP068237:1967991-1968093 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT154721 WP_001277107.1 NZ_CP051663:c2842538-2842272 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT154721 NZ_CP068237:c1968100-1967950 [Klebsiella quasipneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References