Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2165139..2165793 Replicon chromosome
Accession NZ_CP051663
Organism Escherichia coli strain 1162invT2

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag HH200_RS10665 Protein ID WP_000244765.1
Coordinates 2165139..2165546 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag HH200_RS10670 Protein ID WP_000354050.1
Coordinates 2165527..2165793 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH200_RS10645 (2161096) 2161096..2162829 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
HH200_RS10650 (2162835) 2162835..2163545 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HH200_RS10655 (2163570) 2163570..2164466 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HH200_RS10660 (2164578) 2164578..2165099 + 522 WP_001055874.1 flavodoxin FldB -
HH200_RS10665 (2165139) 2165139..2165546 - 408 WP_000244765.1 protein YgfX Toxin
HH200_RS10670 (2165527) 2165527..2165793 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
HH200_RS10675 (2166036) 2166036..2167016 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
HH200_RS10680 (2167093) 2167093..2167752 - 660 WP_000250275.1 hemolysin III family protein -
HH200_RS10685 (2167916) 2167916..2168227 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
HH200_RS10690 (2168272) 2168272..2169705 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T154717 WP_000244765.1 NZ_CP051663:c2165546-2165139 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T154717 NZ_CP068234:c3972783-3972370 [Leclercia adecarboxylata]
GTGGTCCTGTGGCAATCTGATCTACGCGTCTCATGGCGCGCCCAGTGGATGTCGCTTCTGCTCCACGGCCTGGTCGCGGC
TGTTATTCTTCTGATGCCGTGGCCGCTGAGCTACACCCCATTATGGCTGATGCTGCTGTCGCTGGTGGTGTTTGATAGCG
TACGCAGTCAGCGGCGCATTAACGCCCGTCAGGGTGAAATCAAACTGTTTATGGATTCCCGTCTGCACTGGCAGGAGAGC
GAGTGGGAAATTGTCGGCACGCCGTGGATGCTGAACTCCGGCATGATGCTCCGCTTACGCAAAGGCGCGGGTCAACGCTG
CCATCATTTATGGCTTGCGGCAGACAGTATGGATGAAGCGGAGTGGCGGGATCTACGTCGGATGATGTCGCACCAGCCGA
CGCAGGGGCGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT154717 WP_000354050.1 NZ_CP051663:c2165793-2165527 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT154717 NZ_CP068234:c3973030-3972764 [Leclercia adecarboxylata]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGTCGCGGCATGCGCGAACTCGATATCTCCATCATGCCGTT
CTTCGAATACGAATATGACAGCCTGAGCGATGAGGATAAGCATCTCTTCGTTCGCCTGCTGGAGAACGACGATCCCGATT
TATTTAACTGGTTGATGAATCACGGCAAACCCGCCGACGCCGAGCTGCAACGGATGGTGCTTTTAATTCAGACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References