Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 139420..140021 Replicon plasmid pEco1162T7a
Accession NZ_CP051662
Organism Escherichia coli strain 1162T7

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag HH201_RS25520 Protein ID WP_001216034.1
Coordinates 139641..140021 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag HH201_RS25515 Protein ID WP_001190712.1
Coordinates 139420..139641 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH201_RS25505 (HH201_25275) 136401..137684 - 1284 WP_001617890.1 restriction endonuclease subunit S -
HH201_RS25510 (HH201_25280) 137681..139237 - 1557 WP_001617892.1 type I restriction-modification system subunit M -
HH201_RS25515 (HH201_25285) 139420..139641 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HH201_RS25520 (HH201_25290) 139641..140021 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HH201_RS25525 (HH201_25295) 140026..140205 + 180 WP_001513661.1 hypothetical protein -
HH201_RS25530 (HH201_25300) 140233..140511 + 279 Protein_153 pdcB -
HH201_RS25535 (HH201_25305) 140516..140929 + 414 Protein_154 integrase core domain-containing protein -
HH201_RS25540 (HH201_25310) 140879..141214 - 336 WP_169329198.1 type I deoxyribonuclease HsdR -
HH201_RS25545 (HH201_25315) 141424..142404 - 981 WP_000019407.1 IS5-like element IS5 family transposase -
HH201_RS25550 (HH201_25320) 142648..144051 + 1404 WP_001373486.1 S-methylmethionine permease -
HH201_RS25555 (HH201_25325) 144038..144970 + 933 WP_000081352.1 homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catB3 / blaOXA-1 / aac(6')-Ib-cr senB 1..148312 148312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T154701 WP_001216034.1 NZ_CP051662:139641-140021 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T154701 NZ_CP068228:c4143739-4142438 [Shewanella algae]
ATGAGTGGAGCAGCAAACCTTGTCTTGGATATGCATCTTGGTGATCGAATCATAGGTGAGTTGTCATTCGATCCCGCCAC
CGAGAGTTTTGCCGTCAGTTACAGCCAAGATTGGCGGCAAAACGGCTTTCCCATATCACCCATGATCCCTTTGGATGGCA
CAGGAAGCAGCACACAGATCGCCATGTTTCTCGGCAACCTGTTGCCCGAAAACAGGGGCTTGGATTATCTCATCGAATCT
CTTGGTGTATCCAGGGGCAATACCTTTGCCCTTATCCGAGCCATAGGCTTGGATACTGCCGGTGCCGTTGCCTTTTCTCC
CAAGGGGACTGAACTGCCACAGACGGCATTTCGAGAAATCAGTGATGATGAAATCATTTTACGCCTGGAAGAGCCTGAGC
TCTGGCCAATGGAGGTGTGGGATGGCAAGCCCAGGCTGTCGGTAGCCGGGGTACAGTCGAAACTGAATCTGTTCTACAAC
GGTAAGCAATTTGGTTTCGGTGAAGGTGCCTTATCATCGACCCATATCTTGAAGTTCGAAAAGCAGCGGCATTTAGTCAT
CAACGAGTTTCTCACTATGCGTTTGGCGAAGTCGATAGCCATGAATGTCGCGAATGTTGAGATCCGCCATTTTGGCCAGC
ACAAATCATTGTGTGTCGAACGCTTTGATCGTCGTTATTTGCCCGCTGAACAGCGGGTGCTGAGAAGGCATATTATCGAT
AGCTGCCAAGCCCTTGGCTTTAGTGTGAATAAGAAATACGAACGAAATTTTGGTAATGGCCGTGATGTCAGAGATATTCG
CGAAGGTGTTAGCCTGCCCAGGCTGTTTGCTCTTGCGGAGCAATGCGCTAATCCGGCGGCGGCCAAACAGGATATGCTGC
AGTGGACGCTGTTTAATCTACTGAGTGGCAACGCCGATGCTCATGGTAAAAACTACTCCTTCTTCATGACACCGACAGGT
ATGGTGCCTACGCCTTGGTATGACTTGGTTTGCGTGGCCTTGTATGAAGAATTTGAGCAAGAGCTGGCGATGGCGATTGA
TGATGAATTCGACCCAGACAAGATCTACGCCTATCAATTGGCCGCTTTCAGCGAGGATATAGGGTTACCCAGAGCCTTGG
TGAGCAACAGCCTAACCAGAATGGCGACCAGAATAAGCCAAGAAATAGAAGGCGTTATCGCAATGCTCGATGGATTGGAT
AAGGATGAGCAGGCGTTTGTGGCGAGCTACAAAGCACAGTTATTGGCAAGGTGTGAGTGCTATTTGGATATTGCGCCCCA
AATCAATGAGATGGAACTTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT154701 WP_001190712.1 NZ_CP051662:139420-139641 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT154701 NZ_CP068228:c4143978-4143742 [Shewanella algae]
ATGGTCTCGCCATTAACTCCACATTCATTGGGCGCTTTAATTAAGGTCCGTAGAAAAGAAGCTGCACTCACTCTGGATGT
GGCGGCAATGCTTTGTGGTGTCACCAAGAAAACCTTCATCCGGGTCGAGAAGGGTGAAGATGTCTACATCTCTACTGTCT
TCAAGATACTCGATGGCTTGGGGATCCATCTGCTGGCGCAGCCCAAGCCTGATGTTGATTCGACCGGGTGGTACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References