Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4024794..4025412 Replicon chromosome
Accession NZ_CP051661
Organism Escherichia coli strain 1162T7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HH201_RS19495 Protein ID WP_001291435.1
Coordinates 4024794..4025012 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HH201_RS19500 Protein ID WP_000344800.1
Coordinates 4025038..4025412 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH201_RS19460 (4020081) 4020081..4020653 + 573 WP_000779831.1 YbaY family lipoprotein -
HH201_RS19465 (4020684) 4020684..4020995 - 312 WP_000409908.1 MGMT family protein -
HH201_RS19475 (4021374) 4021374..4021727 + 354 WP_000878135.1 DUF1428 family protein -
HH201_RS19480 (4021769) 4021769..4023319 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HH201_RS19485 (4023483) 4023483..4023953 - 471 WP_000136192.1 YlaC family protein -
HH201_RS19490 (4024069) 4024069..4024620 - 552 WP_000102539.1 maltose O-acetyltransferase -
HH201_RS19495 (4024794) 4024794..4025012 - 219 WP_001291435.1 HHA domain-containing protein Toxin
HH201_RS19500 (4025038) 4025038..4025412 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HH201_RS19505 (4025958) 4025958..4029107 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
HH201_RS19510 (4029130) 4029130..4030323 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T154694 WP_001291435.1 NZ_CP051661:c4025012-4024794 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154694 NZ_CP068226:c3582108-3581686 [Shewanella algae]
GTGGCCGGGCAGCGCCATAGGTTTCAACTCAGTTCTTCCTTCAGCCAGTATCTGAGTCTGACGGTGCTGGCTGCTATTTG
CCTGAGCAGCTTTCTTGCCTGGCCGGCGCTGGATTATCCTTTCTATTTATTGTTCAAATACCTATGTTTACTGCTAATGC
TGGCAGGCTTTGGCCTTGCGCTGTGGCGTTTGCGCTGCTGGCAACTCTGTTTCTGGCTTAATGAATTGGGTGAAGGACAG
TTCGAACCCGGTTCGAGTTTCGAACTTAGTGGCAGACCTTGGGTCAGCCCCTTTGTGGTGACTTTTACCTATCAGGGGGA
GGATAACTACGGGCGTTGCTGGCTGTTTGCCGATATGTTTGACGACACAGACTATCGTCACCTGTGTCGTCTATTGTTGC
AGCGCTCAAAGTCCGCTAACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT154694 WP_000344800.1 NZ_CP051661:c4025412-4025038 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT154694 NZ_CP068226:c3582328-3582089 [Shewanella algae]
ATGAGTACCCCCAGGGTTAAGTGGGCATGTCGCCGTGGTATGCTGGAGCTTGATGTACTGTTTCAACCCTTTGTGGAACA
GCATTACGAGACTCTGAGCCCTGAGGATAAGGCCTTGTTTGTTCGTCTGCTTGAGTGTGAAGATCCTGAGCTCTTTGCCT
GGTTTATGGGGCATGAGCAATGTCCGGATCCGCAACTGGCACAGATGGTAGTGCGCGTTCGTGGCCGGGCAGCGCCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References