Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 3478328..3478904 | Replicon | chromosome |
Accession | NZ_CP051661 | ||
Organism | Escherichia coli strain 1162T7 |
Toxin (Protein)
Gene name | shpA | Uniprot ID | A0A061KXE4 |
Locus tag | HH201_RS16875 | Protein ID | WP_001295743.1 |
Coordinates | 3478328..3478615 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | A0A066STF6 |
Locus tag | HH201_RS16880 | Protein ID | WP_000063148.1 |
Coordinates | 3478602..3478904 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HH201_RS16860 (3473988) | 3473988..3475292 | - | 1305 | WP_000535012.1 | restriction endonuclease subunit S | - |
HH201_RS16865 (3475282) | 3475282..3476901 | - | 1620 | WP_001029745.1 | class I SAM-dependent DNA methyltransferase | - |
HH201_RS16870 (3476965) | 3476965..3478131 | - | 1167 | WP_000800831.1 | restriction endonuclease | - |
HH201_RS16875 (3478328) | 3478328..3478615 | + | 288 | WP_001295743.1 | BrnT family toxin | Toxin |
HH201_RS16880 (3478602) | 3478602..3478904 | + | 303 | WP_000063148.1 | BrnA antitoxin family protein | Antitoxin |
HH201_RS16885 (3478938) | 3478938..3479894 | - | 957 | WP_001295745.1 | GTPase | - |
HH201_RS16890 (3479905) | 3479905..3480108 | - | 204 | WP_000467859.1 | YbdD/YjiX family protein | - |
HH201_RS16895 (3480158) | 3480158..3482308 | - | 2151 | WP_001295524.1 | pyruvate/proton symporter BtsT | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11156.62 Da Isoelectric Point: 7.4697
>T154691 WP_001295743.1 NZ_CP051661:3478328-3478615 [Escherichia coli]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG
Download Length: 288 bp
>T154691 NZ_CP068219:1224172-1224357 [Staphylococcus pasteuri]
ATGAGCTTACATTTCACTATTCTTTTTTGGTTATCAATTATATTTTTAATTGCAGGTACAATCGTTCTTGTTACTATGCT
TAAAACTAAAAAAGAATCTAAAAAAGAATCTTATCTTGGCTTCACAATTGTATTCTTTATATTTGGTTTAGCCATGTTAA
TTTATACATTAATATTCGGTTTGTAA
ATGAGCTTACATTTCACTATTCTTTTTTGGTTATCAATTATATTTTTAATTGCAGGTACAATCGTTCTTGTTACTATGCT
TAAAACTAAAAAAGAATCTAAAAAAGAATCTTATCTTGGCTTCACAATTGTATTCTTTATATTTGGTTTAGCCATGTTAA
TTTATACATTAATATTCGGTTTGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11592.12 Da Isoelectric Point: 9.4646
>AT154691 WP_000063148.1 NZ_CP051661:3478602-3478904 [Escherichia coli]
MSMVKHKRGTPSTLDVQHEAELKALANKFDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
MSMVKHKRGTPSTLDVQHEAELKALANKFDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
Download Length: 303 bp
>AT154691 NZ_CP068219:1223896-1224153 [Staphylococcus pasteuri]
ATGAAATTATATTTTCTACACGTAATTAATATTTTATTAACGATATTGTTTGTAATTTTTAATATCGTCATTACAAATAA
CACCAACCTAGATGACACCTTATGGTTAGTGCCCGGATTAATAGTATGTGGTTTGATTATTATTATAAGCTTATTTATAG
CTATTTCTAATAAGGATTTATTAAGTGAAATTCTCTTTTTTATTAATATCATTCTTACCCTATATTACATTTATCCAATT
TTTTACGATTTTCTTTAA
ATGAAATTATATTTTCTACACGTAATTAATATTTTATTAACGATATTGTTTGTAATTTTTAATATCGTCATTACAAATAA
CACCAACCTAGATGACACCTTATGGTTAGTGCCCGGATTAATAGTATGTGGTTTGATTATTATTATAAGCTTATTTATAG
CTATTTCTAATAAGGATTTATTAAGTGAAATTCTCTTTTTTATTAATATCATTCTTACCCTATATTACATTTATCCAATT
TTTTACGATTTTCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061KXE4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A066STF6 |