Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3478328..3478904 Replicon chromosome
Accession NZ_CP051661
Organism Escherichia coli strain 1162T7

Toxin (Protein)


Gene name shpA Uniprot ID A0A061KXE4
Locus tag HH201_RS16875 Protein ID WP_001295743.1
Coordinates 3478328..3478615 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A066STF6
Locus tag HH201_RS16880 Protein ID WP_000063148.1
Coordinates 3478602..3478904 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH201_RS16860 (3473988) 3473988..3475292 - 1305 WP_000535012.1 restriction endonuclease subunit S -
HH201_RS16865 (3475282) 3475282..3476901 - 1620 WP_001029745.1 class I SAM-dependent DNA methyltransferase -
HH201_RS16870 (3476965) 3476965..3478131 - 1167 WP_000800831.1 restriction endonuclease -
HH201_RS16875 (3478328) 3478328..3478615 + 288 WP_001295743.1 BrnT family toxin Toxin
HH201_RS16880 (3478602) 3478602..3478904 + 303 WP_000063148.1 BrnA antitoxin family protein Antitoxin
HH201_RS16885 (3478938) 3478938..3479894 - 957 WP_001295745.1 GTPase -
HH201_RS16890 (3479905) 3479905..3480108 - 204 WP_000467859.1 YbdD/YjiX family protein -
HH201_RS16895 (3480158) 3480158..3482308 - 2151 WP_001295524.1 pyruvate/proton symporter BtsT -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11156.62 Da        Isoelectric Point: 7.4697

>T154691 WP_001295743.1 NZ_CP051661:3478328-3478615 [Escherichia coli]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

>T154691 NZ_CP068219:1224172-1224357 [Staphylococcus pasteuri]
ATGAGCTTACATTTCACTATTCTTTTTTGGTTATCAATTATATTTTTAATTGCAGGTACAATCGTTCTTGTTACTATGCT
TAAAACTAAAAAAGAATCTAAAAAAGAATCTTATCTTGGCTTCACAATTGTATTCTTTATATTTGGTTTAGCCATGTTAA
TTTATACATTAATATTCGGTTTGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11592.12 Da        Isoelectric Point: 9.4646

>AT154691 WP_000063148.1 NZ_CP051661:3478602-3478904 [Escherichia coli]
MSMVKHKRGTPSTLDVQHEAELKALANKFDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT154691 NZ_CP068219:1223896-1224153 [Staphylococcus pasteuri]
ATGAAATTATATTTTCTACACGTAATTAATATTTTATTAACGATATTGTTTGTAATTTTTAATATCGTCATTACAAATAA
CACCAACCTAGATGACACCTTATGGTTAGTGCCCGGATTAATAGTATGTGGTTTGATTATTATTATAAGCTTATTTATAG
CTATTTCTAATAAGGATTTATTAAGTGAAATTCTCTTTTTTATTAATATCATTCTTACCCTATATTACATTTATCCAATT
TTTTACGATTTTCTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A061KXE4


Antitoxin

Source ID Structure
AlphaFold DB A0A066STF6

References