Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3295416..3296011 Replicon chromosome
Accession NZ_CP051661
Organism Escherichia coli strain 1162T7

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HH201_RS15960 Protein ID WP_000239579.1
Coordinates 3295661..3296011 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HH201_RS15955 Protein ID WP_001223208.1
Coordinates 3295416..3295667 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH201_RS15945 (3291081) 3291081..3294860 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
HH201_RS15950 (3294863) 3294863..3295204 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HH201_RS15955 (3295416) 3295416..3295667 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HH201_RS15960 (3295661) 3295661..3296011 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HH201_RS15965 (3296091) 3296091..3296621 - 531 WP_000055075.1 inorganic diphosphatase -
HH201_RS15970 (3296931) 3296931..3297887 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HH201_RS15975 (3298027) 3298027..3299529 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
HH201_RS15980 (3299543) 3299543..3300565 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T154689 WP_000239579.1 NZ_CP051661:3295661-3296011 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T154689 NZ_CP068219:99122-99484 [Staphylococcus pasteuri]
ATGATTAGAAGAGGAGATGTTTATCTAGCAGATTTATCACCTGTTCAAGGGTCCGAACAAGGGGGAGTAAGACCCGTCGT
TATTATTCAAAATGACACAGGTAATAAATATAGTCCAACAGTAATTGTTGCAGCAATTACTGGAAGGATTAACAAAGCTA
AGATACCCACACATGTAGAAATAGAAAAGAAGAAGTATAAACTTGATAAAGATTCTGTAATCTTACTTGAACAAATTCGA
ACGTTAGATAAAAATCGTTTGAAAGAAAAGCTCACATATTTGTCAGAAAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATCAGTCTAGGTTTACATAATTTTAATCATCCAAAGACTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT154689 WP_001223208.1 NZ_CP051661:3295416-3295667 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT154689 NZ_CP068219:98955-99125 [Staphylococcus pasteuri]
ATGTTATCTTTTAATCAAAATAGAAGTTACAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCAATTGAATGTGAAGCGTGCGATTGCAATGAAACATATTTAAATTCTAACGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References