Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1845313..1846147 | Replicon | chromosome |
| Accession | NZ_CP051661 | ||
| Organism | Escherichia coli strain 1162T7 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | HH201_RS09045 | Protein ID | WP_000854690.1 |
| Coordinates | 1845770..1846147 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | HH201_RS09040 | Protein ID | WP_001305076.1 |
| Coordinates | 1845313..1845681 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HH201_RS09000 (1840395) | 1840395..1841522 | + | 1128 | Protein_1766 | hypothetical protein | - |
| HH201_RS09005 (1841598) | 1841598..1842053 | + | 456 | WP_000581502.1 | IrmA family protein | - |
| HH201_RS09010 (1842132) | 1842132..1842365 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| HH201_RS09015 (1842466) | 1842466..1843284 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| HH201_RS09020 (1843339) | 1843339..1843824 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| HH201_RS09025 (1843840) | 1843840..1844316 | + | 477 | WP_001186726.1 | RadC family protein | - |
| HH201_RS09030 (1844379) | 1844379..1844600 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| HH201_RS09035 (1844619) | 1844619..1845263 | + | 645 | WP_000094916.1 | hypothetical protein | - |
| HH201_RS09040 (1845313) | 1845313..1845681 | + | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HH201_RS09045 (1845770) | 1845770..1846147 | + | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| HH201_RS09050 (1846144) | 1846144..1846632 | + | 489 | WP_000761699.1 | DUF5983 family protein | - |
| HH201_RS09055 (1846649) | 1846649..1846846 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| HH201_RS09060 (1846931) | 1846931..1847776 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| HH201_RS09065 (1847845) | 1847845..1848240 | + | 396 | WP_000208384.1 | DUF6088 family protein | - |
| HH201_RS09070 (1848233) | 1848233..1849166 | + | 934 | Protein_1780 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| HH201_RS09075 (1849583) | 1849583..1849753 | + | 171 | Protein_1781 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / ugd / kpsT | 1845313..1867356 | 22043 | |
| - | flank | IS/Tn | - | - | 1849598..1849753 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T154683 WP_000854690.1 NZ_CP051661:1845770-1846147 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T154683 NZ_CP068215:c4292059-4291688 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT154683 WP_001305076.1 NZ_CP051661:1845313-1845681 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT154683 NZ_CP068215:c4292304-4292062 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAGCCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAGCCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|