Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4952019..4952516 Replicon chromosome
Accession NZ_CP051659
Organism Escherichia coli strain 1162C

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag HH202_RS24215 Protein ID WP_001173343.1
Coordinates 4952343..4952516 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag HH202_RS24210 Protein ID WP_001312331.1
Coordinates 4952019..4952315 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH202_RS24200 (4947376) 4947376..4951305 + 3930 WP_001080129.1 autotransporter outer membrane beta-barrel domain-containing protein -
HH202_RS24205 (4951519) 4951519..4951791 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
HH202_RS24210 (4952019) 4952019..4952315 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HH202_RS24215 (4952343) 4952343..4952516 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
HH202_RS24220 (4952635) 4952635..4954152 - 1518 WP_000003806.1 lysine--tRNA ligase -
HH202_RS24225 (4954389) 4954389..4955846 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T154667 WP_001173343.1 NZ_CP051659:4952343-4952516 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T154667 NZ_CP068214:c3906387-3905965 [Serratia ureilytica]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTCTCTCTGTTGACCCACGGCGTCCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCTGCGGTGCAGGGTGAACTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGA
GAATGGCAGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGCTACAGCCTATGGAGGGCAAAAAGCG
CCGTCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT154667 WP_001312331.1 NZ_CP051659:4952019-4952315 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp

>AT154667 NZ_CP068214:c3906634-3906368 [Serratia ureilytica]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTCATCCGTCTGCTCGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAAAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References