Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4136789..4137589 Replicon chromosome
Accession NZ_CP051659
Organism Escherichia coli strain 1162C

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag HH202_RS20480 Protein ID WP_000342452.1
Coordinates 4136789..4137316 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag HH202_RS20485 Protein ID WP_001277107.1
Coordinates 4137323..4137589 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH202_RS20455 (4131865) 4131865..4132632 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HH202_RS20460 (4132629) 4132629..4133906 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
HH202_RS20465 (4133903) 4133903..4134829 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
HH202_RS20470 (4134877) 4134877..4135986 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
HH202_RS20475 (4136409) 4136409..4136792 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
HH202_RS20480 (4136789) 4136789..4137316 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
HH202_RS20485 (4137323) 4137323..4137589 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
HH202_RS20490 (4137738) 4137738..4138841 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
HH202_RS20495 (4139112) 4139112..4139966 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
HH202_RS20500 (4140211) 4140211..4141269 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
HH202_RS20505 (4141262) 4141262..4141930 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T154665 WP_000342452.1 NZ_CP051659:c4137316-4136789 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

>T154665 NZ_CP068214:1738074-1738170 [Serratia ureilytica]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT154665 WP_001277107.1 NZ_CP051659:c4137589-4137323 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT154665 NZ_CP068214:c1738170-1738030 [Serratia ureilytica]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References