Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3460196..3460850 Replicon chromosome
Accession NZ_CP051659
Organism Escherichia coli strain 1162C

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag HH202_RS17055 Protein ID WP_000244765.1
Coordinates 3460196..3460603 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag HH202_RS17060 Protein ID WP_000354050.1
Coordinates 3460584..3460850 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH202_RS17035 (3456153) 3456153..3457886 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
HH202_RS17040 (3457892) 3457892..3458602 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HH202_RS17045 (3458627) 3458627..3459523 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HH202_RS17050 (3459635) 3459635..3460156 + 522 WP_001055874.1 flavodoxin FldB -
HH202_RS17055 (3460196) 3460196..3460603 - 408 WP_000244765.1 protein YgfX Toxin
HH202_RS17060 (3460584) 3460584..3460850 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
HH202_RS17065 (3461093) 3461093..3462073 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
HH202_RS17070 (3462150) 3462150..3462809 - 660 WP_000250275.1 hemolysin III family protein -
HH202_RS17075 (3462973) 3462973..3463284 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
HH202_RS17080 (3463329) 3463329..3464762 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T154661 WP_000244765.1 NZ_CP051659:c3460603-3460196 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T154661 NZ_CP068211:5233687-5233872 [Achromobacter xylosoxidans]
ATGAAGTACAGCGAATTCAGGCGGTGGCTACTACGGCAGGGCGTGAAGTTGGAAGCCCACAAATCCGGCAGCAGCCACTT
CAAAGCAACCCTAGGTGATCGAATGACAGTGTTCCCAGACCACGGCAGTAAAGAGATGGGCACGGGGCTGGTGAACAAGA
TCAAGAAAGACCTGGGCCTGAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT154661 WP_000354050.1 NZ_CP051659:c3460850-3460584 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT154661 NZ_CP068211:5233941-5234351 [Achromobacter xylosoxidans]
ATGTTGACCTACAGCTACACGCTGACGCCGGACACGAACGGCACGTACCTGATCCAGTATCCCGACCTGCCGGAAGGCGC
GGCCGTGAGCGAATCGCCGAACGCCGCCGCCGAAGCCGCAGAAGGCCTGGAAGCGGTGTTGCAGATGTACATCGATGCGC
GCCGCCCTATCCCCATGCCCAGCGGCGTCGGGGATGGTGCGGTGAACGTCGGCGCCATGCGCACCGCTAAGGTGCTGCTG
TCCAACGAGATGGTGCGCCAGGGCGTGCGTAAAGCTGACCTGGCCCGCCGACTGGGCCTACACGCCCCCCAGGTCGACCG
ACTGCTGGATCTGAGCCACAACTCCAAGATGGACGCCATCGAGGCGGCGTGCGCCGAACTCGGTCGCCGCCTCGATGTCT
CGCTGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References