Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2525311..2526142 Replicon chromosome
Accession NZ_CP051659
Organism Escherichia coli strain 1162C

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag HH202_RS12850 Protein ID WP_000854815.1
Coordinates 2525768..2526142 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag HH202_RS12845 Protein ID WP_001280918.1
Coordinates 2525311..2525679 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH202_RS12800 (2520400) 2520400..2521146 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
HH202_RS12805 (2521229) 2521229..2521579 + 351 Protein_2512 hypothetical protein -
HH202_RS12810 (2521595) 2521595..2522005 + 411 WP_000846703.1 hypothetical protein -
HH202_RS12815 (2522226) 2522226..2523044 + 819 WP_001542275.1 DUF932 domain-containing protein -
HH202_RS12820 (2523044) 2523044..2523289 + 246 WP_001164966.1 hypothetical protein -
HH202_RS12825 (2523383) 2523383..2523856 + 474 WP_001542276.1 antirestriction protein -
HH202_RS12830 (2523872) 2523872..2524348 + 477 WP_001186200.1 RadC family protein -
HH202_RS12835 (2524411) 2524411..2524632 + 222 WP_000692345.1 DUF987 domain-containing protein -
HH202_RS12840 (2524651) 2524651..2525295 + 645 WP_000086752.1 hypothetical protein -
HH202_RS12845 (2525311) 2525311..2525679 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HH202_RS12850 (2525768) 2525768..2526142 + 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HH202_RS12855 (2526139) 2526139..2526333 + 195 WP_000988600.1 DUF5983 family protein -
HH202_RS12860 (2526379) 2526379..2526459 + 81 Protein_2523 hypothetical protein -
HH202_RS12865 (2526748) 2526748..2526828 - 81 WP_023441679.1 hypothetical protein -
HH202_RS12870 (2526807) 2526807..2527130 + 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
HH202_RS12875 (2527231) 2527231..2527560 - 330 WP_000450409.1 DUF496 family protein -
HH202_RS12880 (2527732) 2527732..2528790 - 1059 WP_001200889.1 FUSC family protein -
HH202_RS12885 (2528988) 2528988..2529461 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
HH202_RS12890 (2529580) 2529580..2530746 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T154659 WP_000854815.1 NZ_CP051659:2525768-2526142 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T154659 NZ_CP068211:c2165200-2164625 [Achromobacter xylosoxidans]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACCGGGCAATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGACCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTACTGGATCTGGACGCGGCCGCCGTGGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGAGGTGGACCGCTATCTCGAAATCCTGCTGCGCCAGGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT154659 WP_001280918.1 NZ_CP051659:2525311-2525679 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT154659 NZ_CP068211:c2165667-2165197 [Achromobacter xylosoxidans]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTGAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTCGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References