Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1982197..1983785 Replicon chromosome
Accession NZ_CP051659
Organism Escherichia coli strain 1162C

Toxin (Protein)


Gene name hipA Uniprot ID A0A061YM43
Locus tag HH202_RS10015 Protein ID WP_001125411.1
Coordinates 1982197..1983519 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A061YNW4
Locus tag HH202_RS10020 Protein ID WP_001296076.1
Coordinates 1983519..1983785 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH202_RS10005 (1979651) 1979651..1980361 - 711 WP_001195176.1 fimbria/pilus periplasmic chaperone -
HH202_RS10010 (1980723) 1980723..1981286 - 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
HH202_RS10015 (1982197) 1982197..1983519 - 1323 WP_001125411.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HH202_RS10020 (1983519) 1983519..1983785 - 267 WP_001296076.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HH202_RS10025 (1984093) 1984093..1984851 + 759 WP_001286537.1 trans-aconitate 2-methyltransferase -
HH202_RS10030 (1984855) 1984855..1985769 - 915 WP_001296077.1 bestrophin family protein -
HH202_RS10035 (1985966) 1985966..1987417 - 1452 WP_000854638.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49329.96 Da        Isoelectric Point: 7.7906

>T154650 WP_001125411.1 NZ_CP051659:c1983519-1982197 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Download         Length: 1323 bp

>T154650 NZ_CP068202:48880-49182 [Acinetobacter johnsonii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTTACTAAGTTAAAAGACCAGCAGGCAAAAAGACGTATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTCTCTGAATTACGTTTCT
TCTTTGGACCTGGCTACAGGATCTATTACTGTAAGCAAGGGCAAAGGGTCGTTATTCTTTTAGCAGGCGGAGACAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAACTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9987.34 Da        Isoelectric Point: 4.9632

>AT154650 WP_001296076.1 NZ_CP051659:c1983785-1983519 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp

>AT154650 NZ_CP068202:49183-49464 [Acinetobacter johnsonii]
ATGGCTATCAAACTTCGTAAATGGGACAGTGCTGAACATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATAGATGAATCTAATGGTGATGCGGCATTCATTGCAAAAGCTTTAGGTAATATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCAAGAGACACAGGTTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGCGATGTAAATCCAAGCTTTGATACTGTT
ATTAAAGTGGTAAAAGCGCTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YM43

Antitoxin

Source ID Structure
AlphaFold DB A0A061YNW4

References