Detailed information of TA system TA154643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 565326..567015
• Replicon: chromosome
• Accession: NZ_CP051659
• Organism: Escherichia coli strain 1162C

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: HH202_RS02760
• Protein ID: WP_000365807.1
• Coordinates: 566095..567015 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HH202_RS02755
• Protein ID: WP_001295795.1
• Coordinates: 565326..566108 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HH202_RS02750 (561944)	561944..565042	-	3099	WP_000673070.1	type I restriction endonuclease	-
HH202_RS02755 (565326)	565326..566108	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
HH202_RS02760 (566095)	566095..567015	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HH202_RS02765 (567180)	567180..567956	-	777	WP_000171155.1	site-specific integrase	-
HH202_RS02770 (568164)	568164..568499	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
HH202_RS02775 (568726)	568726..568884	-	159	Protein_542	integrase	-
HH202_RS02780 (568933)	568933..569118	+	186	WP_000146240.1	hypothetical protein	-
HH202_RS02785 (569333)	569333..569947	+	615	WP_001019923.1	YagU family protein	-
HH202_RS02790 (570018)	570018..570184	+	167	Protein_545	tail fiber assembly protein	-
HH202_RS02795 (570196)	570196..570525	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
HH202_RS02800 (570832)	570832..571542	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T154643 WP_000365807.1 NZ_CP051659:566095-567015 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T154643 NZ_CP068195:c407805-407413 [Acinetobacter johnsonii]
ATGAATATTATTTGTTTTCCATTTGAGCGTGTGATTGAGATTAATGCCTTTATTTTAGCTACAGAAAAAGGTATGAAAGG
TGCATCGGATGTTGGGAAGTTGCAAGGTGCTTTAGCTCGTGTGGATAATGCGATTGTTTATGAGGGTTTAGACGATGTAT
TTGAAATAGCAGCTAAATATGCCTCAAGTATTGCGAATGCACACGCATTATCTGATGCGAATAAGCGGACTGGATTAGCT
GTTGCTTTAGAATATTTGTCTTTGAATGATTATGAATTGTTACAAGATAACGAGCTATTAGCTGATGCTGTCAGAGACTT
AGTAATCGGTGAAGTCACTGAAAATGATTTTGCAGATATTTTATATGCCCATTATGTAGCAAATGGTGGATGA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT154643 WP_001295795.1 NZ_CP051659:565326-566108 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT154643 NZ_CP068195:c407975-407805 [Acinetobacter johnsonii]
ATGAATAAAAAAGTAGAAAAGTATGGTGTTGCTGCGGTTGAACGTCCAAAAATTCAGGCAACGAAGCAATTGGATTTGTC
AGGTGATACTGGTCGTCAGATCGTAAAGTCAGAAACAAAACTAGCCTTACGTACACATAGTAAGACATTTAAACGCCTTG
CAGATATGTAA

Structures

Toxin

• AlphaFold DB: A0A061KTE0