Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 6402..6997 Replicon chromosome
Accession NZ_CP051659
Organism Escherichia coli strain 1162C

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HH202_RS00030 Protein ID WP_000239579.1
Coordinates 6647..6997 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HH202_RS00025 Protein ID WP_001223208.1
Coordinates 6402..6653 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HH202_RS00015 (2067) 2067..5846 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
HH202_RS00020 (5849) 5849..6190 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HH202_RS00025 (6402) 6402..6653 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HH202_RS00030 (6647) 6647..6997 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HH202_RS00035 (7077) 7077..7607 - 531 WP_000055075.1 inorganic diphosphatase -
HH202_RS00040 (7917) 7917..8873 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HH202_RS00045 (9013) 9013..10515 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
HH202_RS00050 (10529) 10529..11551 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T154639 WP_000239579.1 NZ_CP051659:6647-6997 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T154639 NZ_CP068187:3037223-3037615 [Acinetobacter johnsonii]
ATGAATATTATTTGTTTTCCATTTGAGCGTGTGATTGAGATTAATGCCTTTATTTTAGCTACAGAAAAAGGTATGAAAGG
TGCATCGGATGTTGGGAAGTTGCAAGGTGCTTTAGCTCGTGTGGATAATGCGATTGTTTATGAGGGTTTAGACGATGTAT
TTGAAATAGCAGCTAAATATGCCTCAAGTATTGCGAATGCACACGCATTATCTGATGCGAATAAGCGGACTGGATTAGCT
GTTGCTTTAGAATATTTGTCTTTGAATGATTATGAATTGTTACAAGATAACGAGCTATTAGCTGATGCTGTCAGAGACTT
AGTAATCGGTGAAGTCACTGAAAATGATTTTGCAGATATTTTATATGCCCATTATGTAGCAAATGGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT154639 WP_001223208.1 NZ_CP051659:6402-6653 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT154639 NZ_CP068187:3037053-3037223 [Acinetobacter johnsonii]
ATGAATAAAAAAGTAGAAAAGTATGGTGTTGCTGCGGTTGAACGTCCAAAAATTCAGGCAACGAAGCAATTGGATTTGTC
AGGTGATACTGGTCGTCAGATCGTAAAGTCAGAAACAAAACTAGCCTTACGTACACATAGTAAGACATTTAAACGCCTTG
CAGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References