Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 8962..9455 Replicon plasmid pSJ7-2
Accession NZ_CP051658
Organism Escherichia coli strain SJ7

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag F7D02_RS27490 Protein ID WP_001230709.1
Coordinates 8962..9216 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag F7D02_RS27495 Protein ID WP_000151456.1
Coordinates 9213..9455 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D02_RS27475 4305..7289 + 2985 WP_032275676.1 Tn3 family transposase -
F7D02_RS27480 7804..8319 + 516 WP_001025393.1 J domain-containing protein -
F7D02_RS27485 8423..8965 + 543 WP_001083909.1 hypothetical protein -
F7D02_RS27490 8962..9216 + 255 WP_001230709.1 hypothetical protein Toxin
F7D02_RS27495 9213..9455 + 243 WP_000151456.1 hypothetical protein Antitoxin
F7D02_RS27500 10026..10319 + 294 WP_000673431.1 hypothetical protein -
F7D02_RS27505 10624..10911 + 288 WP_000606467.1 hypothetical protein -
F7D02_RS27510 11339..11572 + 234 WP_000093745.1 hypothetical protein -
F7D02_RS27515 11648..11950 + 303 WP_000379301.1 hypothetical protein -
F7D02_RS27520 12186..12371 + 186 Protein_15 hypothetical protein -
F7D02_RS27525 12482..13303 + 822 WP_001234372.1 DUF945 domain-containing protein -
F7D02_RS27530 13600..14202 - 603 WP_072205450.1 transglycosylase SLT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..53543 53543


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(5-127)

Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T154638 WP_001230709.1 NZ_CP051658:8962-9216 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

>T154638 NZ_CP068187:c1819066-1818680 [Acinetobacter johnsonii]
ATGGAACATCGTCATTTTCAACTTAAACCCAGCCGTCTGGCTTATGTGTTTCAGTTGTCGATTTATGCCGTTCTGATGCT
GGTCTTGTATCAGCTACTTCCTTTAGGACTGTGGCTGATCGCTTTGGTTGCTGGCTTTGTGCTGTATTTGTTTTTTCTAC
GTGGGCCGCAACATTTTCAGCTTCAGCATTTAGATGGTCGTGATTGGTCTTTGTCACTTCAGAAACAAACCAATGTGCAA
CGAGTGCAAATCAGCCATATTGTTGATCATCGTGCTTATATTGTGATTTATTTTCAACACTTTAGAGCAAAACCGATGTT
GGTTTGGTGTGATCAGTTACCCATCACGCAATGGAAAGCCCTGAAAATACTCACTAAAATGCAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT154638 WP_000151456.1 NZ_CP051658:9213-9455 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp

>AT154638 NZ_CP068187:c1819329-1819072 [Acinetobacter johnsonii]
ATGACGGAAGAAATGAGCTTGGAAGAACGTAAAGTAATCTACCGTGCACGTCGTGGTTTAAAAGAAATTGATGTGTACTT
TGACCCTTATGTGAAAAATTATTATCTTCAGGCAGATCCTGCGGAAAAGGCCATGTTTGCGGCCTTGGTTGAACAAGAAG
ATCCAGATTTGTTGGATTGGTTTATGGAAGTTTCTGAGCCGCCACGCCCTGAAATGAAAACCTTGATTCAAAAATTAAAG
CATTATGTACACGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References