Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 56091..56647 Replicon plasmid pRM13745-2
Accession NZ_CP051655
Organism Escherichia coli strain RM13745

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F7D05_RS26380 Protein ID WP_050939058.1
Coordinates 56372..56647 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F7D05_RS26375 Protein ID WP_050939060.1
Coordinates 56091..56372 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D05_RS26345 51815..52819 + 1005 WP_050939068.1 IS110 family transposase -
F7D05_RS26350 53070..53735 - 666 WP_072095473.1 transposase -
F7D05_RS26355 53770..53928 + 159 WP_077793267.1 toxin-antitoxin system protein -
F7D05_RS26360 53925..54202 + 278 Protein_57 type II toxin-antitoxin system RelE/ParE family toxin -
F7D05_RS26365 54248..54715 + 468 WP_050939063.1 DNA polymerase III subunit epsilon -
F7D05_RS26370 55040..55498 + 459 WP_050939085.1 hypothetical protein -
F7D05_RS26375 56091..56372 + 282 WP_050939060.1 ribbon-helix-helix protein, CopG family Antitoxin
F7D05_RS26380 56372..56647 + 276 WP_050939058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F7D05_RS26385 56753..57034 + 282 WP_050939055.1 hypothetical protein -
F7D05_RS26390 57271..57522 - 252 WP_050939053.1 hypothetical protein -
F7D05_RS26395 58129..59281 - 1153 Protein_64 IS3 family transposase -
F7D05_RS26400 59340..59582 + 243 Protein_65 transposase -
F7D05_RS26405 60847..61365 + 519 WP_050939047.1 alpha-hemolysin-activating lysine-acyltransferase HlyC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyC / hlyA / hlyB / hlyB / hlyD / hlyD 1..70650 70650
- flank IS/Tn - - 58988..59281 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10753.44 Da        Isoelectric Point: 9.9324

>T154629 WP_050939058.1 NZ_CP051655:56372-56647 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFETREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T154629 NZ_CP068170:1790864-1791133 [Erysipelatoclostridium ramosum]
ATGAGATATAAAGTTGTTTTTTCAAAAACTGTTTTAAAACAGTTAAAGAAGATGGATAAATATACTAAACTTTTATTGAT
AAATTGGATTGAGAATAATCTTGATGGTTGTGATGATCCTAGAGTACACGGTAAGGCTTTAAGTGCTAATCGTAGCGGAC
AATGGCGGTATAGAATTGGTGATTATCGTTTAATATGTGAGATTGAAGATAATAAACTTGTTATTTTTGCTTTATCAGTT
GGTCATCGTAAAGATGTTTATAAGAGATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10335.74 Da        Isoelectric Point: 6.4601

>AT154629 WP_050939060.1 NZ_CP051655:56091-56372 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEERNRLTLEALDDVTSGQVIDHQAVQAWA
DSLSTDNPLSVPR

Download         Length: 282 bp

>AT154629 NZ_CP068170:1790649-1790867 [Erysipelatoclostridium ramosum]
ATGAGTTTTTCAATGAGATTAAGTCAGGAAGAAGAAAGTCTTTTTAAGAGTTACGCTAAATTGCATGGAATCAGTTTATC
CGAAGCATTGAAAAGAGCGTTATTGGAAAAAATTGAAGATGAATATGATATTAATATTGCTGAATCTGCATATAAAGAAT
ATTTAAAAGATCCAGTTACTTATTCTATGGACGATGTAAAGAAAGAGCTAGGGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References