Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4752896..4753431 Replicon chromosome
Accession NZ_CP051652
Organism Pectobacterium carotovorum strain WPP14

Toxin (Protein)


Gene name relE Uniprot ID A0A837DHH7
Locus tag HER17_RS21235 Protein ID WP_010296545.1
Coordinates 4753144..4753431 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837DL69
Locus tag HER17_RS21230 Protein ID WP_010296546.1
Coordinates 4752896..4753147 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER17_RS21210 4749360..4749797 + 438 WP_010296551.1 RICIN domain-containing protein -
HER17_RS21215 4750042..4750665 - 624 WP_039474438.1 LysE family translocator -
HER17_RS21220 4750944..4751699 + 756 WP_010296548.1 thiol:disulfide interchange protein DsbG -
HER17_RS21225 4751734..4752639 - 906 WP_029367632.1 siderophore-interacting protein -
HER17_RS21230 4752896..4753147 + 252 WP_010296546.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HER17_RS21235 4753144..4753431 + 288 WP_010296545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HER17_RS21240 4753527..4754879 - 1353 WP_010296544.1 glutathione-disulfide reductase -
HER17_RS21245 4755008..4755850 - 843 WP_010296540.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
HER17_RS21250 4756132..4756515 - 384 WP_010296537.1 TfoX/Sxy family protein -
HER17_RS21255 4756638..4757936 - 1299 WP_029367625.1 alkyl/aryl-sulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.08 Da        Isoelectric Point: 10.0867

>T154615 WP_010296545.1 NZ_CP051652:4753144-4753431 [Pectobacterium carotovorum]
MSYSVKFREDALKEWLKLDKAIQQQFAKKLKKCCENPHIPAAKLRGMKDCYKIKLRTSGFCLVYEVIDDVLVIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T154615 NZ_CP068159:c953244-952951 [Corynebacterium riegelii]
GTGAAGGAAGTAACATTTTCAGCGTTCGACGCAAGCAAATACCTCGATAGCCAAGAAGCAATGAACGATTACCTGGCTAT
CGCACTCGAAGACGGCGATACGAAAACCGTACAGGTGGTTTTGCGTGACATTGCAAGAGCACACGGCATGAGCCAGCTCG
CTAAAGAGACTCAACTCAACCGTGAATCCCTCTACAAGTCACTATCAAAAGACGGTAACCCGTCCTTTGCGGCTATCACG
AAAATCATGAAAGCCCTAGGGCTCAAAATAACTCTCGCTACACAAAATGCCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9131.50 Da        Isoelectric Point: 4.0785

>AT154615 WP_010296546.1 NZ_CP051652:4752896-4753147 [Pectobacterium carotovorum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVEVDLD
SFL

Download         Length: 252 bp

>AT154615 NZ_CP068159:c953549-953241 [Corynebacterium riegelii]
GTGGAGATCATTTCCAGCAGCTTGTTTGACGCCTGGTTAGGTGAACTAAAAGACAAACATGCTCAGCGGCGCATTTTGTA
TGCAATAGCACGATGCGAAGCACACGGAAGAATGATTGGAGACATCAAACCCGTTGGCGAGAAGGTTAGCGAGATGAGAT
TTCATTTCGGGCCCGGCTATCGGGTGTACTACACCCGACTAGGCGCAATAACGGTTTTCCTGCTGGCCGGAGGAGATAAA
TCCAGCCAGGATAAAGATATTCGAACCGCTCAAAAGCTCGCACAACAGGTAAGGGAGGAACAGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837DHH7

Antitoxin

Source ID Structure
AlphaFold DB A0A837DL69

References